Desamido Collagen
INCI: DESAMIDO COLLAGEN
Reviewed by Rosie · Last updated 20 Jul 2026
Also known as: Desamido Collagen
A breakdown product of collagen that conditions skin and hair whilst forming a protective film
Best For Skin Types
All, Dry, Mature
Addresses
Usage Frequency
Daily
What Is Desamido Collagen?
Desamido collagen is a derivative of collagen that has undergone partial hydrolysis, resulting in smaller molecular fragments. These fragments retain many of collagen's conditioning properties whilst being more easily incorporated into skincare and haircare formulations.
In cosmetic products, it functions primarily as a skin and hair conditioner, and can form a light film on the skin's surface. Unlike intact collagen molecules, which are too large to penetrate the skin barrier, desamido collagen's smaller size allows it to interact more effectively with the outer layers of skin.
Benefits for Your Skin
How It Works
Desamido collagen works through two primary mechanisms. First, it forms a thin, invisible film across the skin's surface, which can help reduce transepidermal water loss and create a temporary smoothing effect. Second, it acts as a humectant and conditioner, drawing moisture into the outer layers of skin and hair fibres, improving their appearance and feel.
The smaller molecular size of desamido collagen compared to native collagen means it can penetrate slightly deeper into the stratum corneum (the skin's outermost layer), enhancing its conditioning effect without the occlusive heaviness of larger protein molecules.
Clinical Evidence & References
Desamido collagen is widely used in cosmetic formulations for its film-forming and conditioning properties, though human clinical studies specifically examining its efficacy are limited. The ingredient has a long history of use in skincare and is generally recognised as safe for topical application.
Most evidence for its benefits comes from in vitro studies and consumer feedback rather than large-scale clinical trials. It appears effective at improving skin smoothness and hydration in the short term, though any anti-ageing effects are likely modest and temporary rather than producing structural changes to skin.
How to Use
Desamido collagen works well in serums, moisturisers, and conditioning treatments. It is typically included at low concentrations and pairs well with other hydrating and occlusive ingredients. Since it forms a surface film, applying it to damp skin can enhance hydration, and layering with an occlusive moisturiser will help lock in these benefits. It can be used daily as part of a standard skincare routine.
Safety & Precautions
Frequently Asked Questions
From the Clinic
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Take the skin quizRelated Ingredients
Copaifera Officinalis Resin
A resinous film-former derived from South American copaiba trees
Corn Starch Modified
A modified starch that absorbs moisture and helps formulations maintain their texture
Corn Starch/Maltodextrin Crosspolymer
A film-forming polymer that creates a smooth, protective layer on skin
Dibutyl Lauroyl Glutamide
A conditioning agent that forms a protective layer on skin and hair
Diethyl Phthalate
A synthetic chemical used to improve texture and preserve fragrance in cosmetic formulations
Dilinoleic Acid/Butanediol Copolymer
A synthetic polymer that forms a flexible protective layer on the skin surface
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