Disodium Flavine Adenine Dinucleotide
INCI: DISODIUM FLAVINE ADENINE DINUCLEOTIDE
Reviewed by Emma · Last updated 14 Aug 2026
A coenzyme that supports cellular energy metabolism in skincare formulations
Best For Skin Types
All
Addresses
Usage Frequency
Daily
What Is Disodium Flavine Adenine Dinucleotide?
Disodium flavine adenine dinucleotide (FAD) is a naturally occurring coenzyme derived from B vitamins. In cosmetic formulations, it functions primarily as a viscosity controlling agent, helping to adjust the texture and consistency of skincare products.
As a derivative of riboflavin (vitamin B2), FAD plays a role in cellular energy production in biological systems. When used in skincare, it may offer antioxidant properties, though its primary cosmetic function remains texture modification rather than direct skin treatment.
How It Works
FAD is a coenzyme involved in oxidation-reduction reactions that generate cellular energy (ATP). When present in skincare, it may be absorbed through the skin and contribute to mitochondrial function in skin cells, potentially supporting cellular repair and resilience.
Its viscosity-controlling properties work by modifying how fluid or thick a formula feels, which can improve spreadability and application comfort without affecting the formula's stability.
Clinical Evidence & References
Research on FAD in cosmetic applications is limited. Most evidence for its benefits comes from studies of vitamin B2 (riboflavin) in general, which shows antioxidant and anti-inflammatory potential. However, direct clinical evidence for topical FAD specifically in skincare products remains sparse.
The ingredient is generally recognised as safe in cosmetics, though more robust human studies would help establish its efficacy in topical formulations. Current use is largely based on theoretical benefits from its biochemical role rather than extensive clinical data.
How to Use
FAD is typically used as a supporting ingredient rather than a primary active, so it works well in combination with other antioxidants or vitamins. Apply as part of your regular skincare routine without special timing considerations, though pairing with sunscreen during the day may enhance antioxidant protection.
Safety & Precautions
Frequently Asked Questions
From the Clinic
Not sure what your skin actually needs?
Two minutes, a few questions, and we’ll point you at what matters — no guesswork.
Take the skin quizRelated Ingredients
Dipentaerythrityl Tetrahydroxystearate/Tetraisostearate
A thickening agent and skin conditioner derived from fatty acids
Dipotassium Azelate
A potassium salt that helps regulate product texture and stability
Dipropylene Glycol
Synthetic slip agent, texturizer, and solvent
Dm Hydantoin
A humectant and preservative booster commonly used in hair and personal care formulations
Eremophila Mitchellii Wood Oil
A botanical binding oil with potential conditioning properties for skincare formulations
Ethyl Methylphenylglycidate
A synthetic fragrance compound that adds scent and helps control product texture
Learn More About Skincare Ingredients
Explore our comprehensive ingredient glossary to understand what's in your products.
Browse All IngredientsShop Our Products
Find professional skincare solutions at Skintique.