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Epigallocatechin Gallate …

INCI: EPIGALLOCATECHIN GALLATE/BIOTIN/COLLAGEN/MOUSE FIBROBLAST CONDITIONED MEDIA

Reviewed by Kate · Last updated 20 Jul 2026

Also known as: Epigallocatechin Gallate/biotin/collagen/mouse Fibroblast Conditioned Media

A blend of plant and biological compounds targeting visible signs of ageing

Best For Skin Types

All, Mature

Addresses

Fine lines, Elasticity, Texture, Firmness

Usage Frequency

Daily

What Is Epigallocatechin Gallate …?

This ingredient combines several active components: epigallocatechin gallate (EGCG), a polyphenol derived from green tea; biotin, a B-complex vitamin; collagen, a structural protein; and mouse fibroblast conditioned media, a cell-culture derived ingredient containing growth factors and proteins produced by skin cells in laboratory conditions.

Together, these components are designed to work synergistically on skin firmness, elasticity and overall appearance. The formulation targets multiple pathways involved in skin ageing, though each component contributes differently to the overall effect.

Benefits for Your Skin

How It Works

EGCG works as an antioxidant, reducing oxidative stress that accumulates in skin over time. Biotin supports keratin and collagen synthesis at the cellular level. The collagen component provides structural scaffolding, whilst fibroblast conditioned media delivers a range of growth factors and signalling molecules that communicate with skin cells to support their natural repair and renewal processes.

This multi-mechanism approach means the ingredient targets ageing from several angles simultaneously, rather than relying on a single pathway.

Clinical Evidence & References

Research on EGCG in skincare shows antioxidant and anti-inflammatory benefits, with some evidence for improved skin texture with consistent use. Biotin's role in skin health is established, though oral supplementation research is more robust than topical application. Collagen as a topical ingredient has mixed evidence; whilst it provides temporary hydration and smoothing, whether it penetrates meaningfully into deeper skin layers remains debated.

Fibroblast conditioned media is a newer ingredient category, and whilst individual growth factors have demonstrated efficacy in research settings, the evidence for this specific formulation is limited. The synergistic benefit of combining all four components is not yet well-established in peer-reviewed literature, so claims should be treated as exploratory rather than proven.

How to Use

Apply to clean, dry skin as part of your routine, typically in a serum or cream format. These multi-component blends often work best with consistent use over several weeks to allow cellular changes to accumulate. Layer with other active ingredients thoughtfully, as combining too many actives may irritate sensitive skin or reduce efficacy.

Safety & Precautions

Generally well-tolerated in most skin types. EGCG and biotin are established safe cosmetic ingredients. Those with very sensitive skin or active inflammatory conditions should introduce gradually. No significant cautions reported, though patch testing is advisable before full facial application.

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