Grape Seed Oil Polyglyceryl-6 Esters
INCI: GRAPE SEED OIL POLYGLYCERYL-6 ESTERS
Reviewed by Kate · Last updated 2 Jun 2026
Also known as: Grape Seed Oil Polyglyceryl-6 Esters
A plant-derived cleansing agent that removes oil-based impurities whilst conditioning the skin
Best For Skin Types
All, Sensitive, Oily, Combination
Addresses
Usage Frequency
Daily
What Is Grape Seed Oil Polyglyceryl-6 Esters?
Grape Seed Oil Polyglyceryl-6 Esters is a surfactant derived from grape seed oil and polyglycerin. It functions as a mild cleanser that helps lift oils, makeup and impurities from the skin surface whilst maintaining hydration. The polyglyceryl component allows the oil-based grape seed extract to dissolve in water, making it useful in both water-based and oil-based formulations.
This ingredient is commonly used in cleansing products, micellar waters and makeup removers. Its dual nature as both an oil and a water-soluble compound means it can bridge hydrophobic (oil) and hydrophilic (water) substances, which is why it works well as an emulsion stabiliser in creams and lotions.
How It Works
The ingredient works through its molecular structure: the grape seed oil end is lipophilic (oil-loving) and attracts oil-based impurities, whilst the polyglyceryl end is hydrophilic (water-loving) and interacts with water. This allows it to suspend oils and dirt in a formulation where they can be rinsed away, similar to how traditional surfactants work in cleansers.
When used in leave-on products like creams, the ingredient acts as an emulsion stabiliser, helping oil and water phases remain blended together rather than separating. The grape seed oil component also provides a thin occlusive layer that can help prevent transepidermal water loss.
Clinical Evidence & References
Limited peer-reviewed data exists specifically for Grape Seed Oil Polyglyceryl-6 Esters as a standalone ingredient. However, grape seed oil itself has been studied for its antioxidant and skin-conditioning properties, with some research suggesting potential benefits for skin barrier function and mild anti-inflammatory activity.
The polyglyceryl esters as a class are generally regarded as mild, low-irritancy surfactants. Practical evidence from widespread cosmetic use suggests the ingredient is well-tolerated in formulations, though large-scale clinical studies comparing this specific ingredient to alternatives are not readily available in published literature.
How to Use
This ingredient works best as part of a complete formulation rather than as a standalone product. If using a cleanser containing this ingredient, apply to damp skin, massage gently, and rinse thoroughly with water. In leave-on products, follow standard product instructions. No additional buffering or pH consideration is needed on the user's part.
Safety & Precautions
Frequently Asked Questions
From the Clinic
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