HEPES
Reviewed by Kate · Last updated 18 Aug 2026
Also known as: Sulfonic Acid, Hydroxyethyl Piperazine Ethane Sulfonic Acid
This synthetically-derived acid activates natural enzymes
EWG Safety Score
What Is HEPES?
This synthetically-derived acid activates natural enzymes in the skin to help break the bonds that bind dead skin cells to the surface, enabling even exfoliation without the need for harsh physical scrubbing.
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