Hesperidin Methyl Chalcone
INCI: Hesperidin methylchalcone
Reviewed by Emma · Last updated 14 Aug 2026
Also known as: Hesperidin methylchalcone, Hesperidin methyl chalcone, HMC, EYELISS, Methyl hesperidin chalcone
Synthetic antioxidant Derived from hesperidin, which is found in citrus fruit
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What Is Hesperidin Methyl Chalcone?
Hesperidin methyl chalcone is a synthetic antioxidant and a derivative of the bioflavonoid hesperidin, which is found in citrus fruit.
Research has shown that applied topically, hesperidin methyl chalcone helps protect skin from UV damage, though it is not an approved sunscreen ingredient. Studies also show it is a soothing ingredient that possesses calming and anti-redness properties.
In its raw form, it is a yellow powder. Typical usage levels in skin care range from 0.1–3%. It is not known to be a safety or irritancy risk.
Benefits for Your Skin
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A lipid-soluble antioxidant derived from citrus flavonoids
Hexapeptide-11
Hexapeptide-11 is classified as a synthetic ingredient, although it can be initially derived from yeast (Saccharomyces cerevisiae) before undergoing synthesis for high purity. As a cosmetic ingredient, it is supplied as a powder or liquid solution. Suppliers recommend usage levels between 0.001% to 0.01%.
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A stabilised vitamin C derivative that protects skin whilst supporting hydration
Hexylresorcinol
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