Hexapeptide-11
Reviewed by Rosie · Last updated 14 Aug 2026
Hexapeptide-11 is classified as a synthetic ingredient, although it can be initially derived from yeast (Saccharomyces cerevisiae) before undergoing synthesis for high purity. As a cosmetic ingredient, it is supplied as a powder or liquid solution. Suppliers recommend usage levels between 0.001% to 0.01%.
EWG Safety Score
What Is Hexapeptide-11?
Hexapeptide-11 is what’s known in the world of skin care as a signaling peptide. It is made up of amino acids including alanine, phenylalanine, proline and valine. Research shows hexapeptide-11 has a positive impact on skin’s elasticity, as well as other factors related to skin’s firmness and hydration. Additionally, it offers antioxidant properties to help protect skin against environmental stressors.
Preliminary research indicates that hexapeptide-11 shows promise for improving skin’s healthspan (a.k.a. longevity) due to the way it interacts with senescent (no longer performing their usual functions) cells. We’ll continue to watch this space and update as new research comes to light.
Hexapeptide-11 is classified as a synthetic ingredient, although it can be initially derived from yeast (Saccharomyces cerevisiae) before undergoing synthesis for high purity. As a cosmetic ingredient, it is supplied as a powder or liquid solution. Suppliers recommend usage levels between 0.001% to 0.01%.
Clinical Evidence & References
- Active Peptide (supplier info), Accessed February 2023, ePublication
- Personal Care Products Council, Accessed February 2023, ePublication
- Journal of Cosmetic Dermatology, April 2022, pages 2,865–2,870
- Skin Pharmacology and Physiology, June 2021, pages 194-201
- Redox Biology, August 2015, pages 205-215
Frequently Asked Questions
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