Peptides

Hexapeptide-10

INCI: HEXAPEPTIDE-10

Reviewed by Daisy · Last updated 14 Aug 2026

A peptide that supports skin hydration and moisture retention

Best For Skin Types

All, Dry, Mature, Sensitive

Addresses

Dryness, Hydration, Barrier repair

Usage Frequency

Daily

What Is Hexapeptide-10?

Hexapeptide-10 is a short chain peptide—a fragment composed of ten amino acids. Peptides are naturally occurring building blocks found throughout the skin, and this particular ingredient functions primarily as a humectant, meaning it draws moisture into the outer layers of the skin.

In skincare formulations, hexapeptide-10 works to enhance the skin's ability to retain water, helping to maintain hydration levels throughout the day. This makes it a useful addition to moisturisers and hydrating serums.

How It Works

Hexapeptide-10 acts as a humectant by drawing water molecules from the environment and deeper skin layers into the epidermis. This process helps to plump the outer layer of skin and improve its overall hydration state, which can contribute to a smoother appearance and support the skin barrier's function.

By maintaining adequate moisture levels in the epidermis, this ingredient may indirectly support the skin's natural repair processes and resilience, particularly in individuals with compromised or dehydrated skin.

Clinical Evidence & References

Research on skin ageing demonstrates that loss of hydration and breakdown of the skin barrier are hallmarks of ageing skin. Maintaining adequate moisture levels in the epidermis is therefore considered supportive of overall skin health and appearance, particularly in mature or dehydrated skin types.

However, specific clinical evidence for hexapeptide-10 itself is limited in published literature. Most evidence for its benefits is derived from its function as a humectant and from the general understanding that peptides can support skin hydration and barrier function. Further targeted research would strengthen confidence in its efficacy.

How to Use

Hexapeptide-10 is best used as part of a hydrating serum or moisturiser applied to clean, damp skin. Applying it to slightly damp skin can enhance its humectant effect. It layers well with other hydrating ingredients and can be used daily as part of both morning and evening routines. If you have very dry skin, consider using it alongside an occlusive moisturiser to lock in the hydration it provides.

Safety & Precautions

Hexapeptide-10 is generally well-tolerated across skin types. As a peptide, it is unlikely to cause irritation, though those with sensitivities to peptide-based products should patch test first.

Frequently Asked Questions

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