Ilex Guayusa Leaf Extract
INCI: ILEX GUAYUSA LEAF EXTRACT
Reviewed by Daisy · Last updated 14 Aug 2026
A plant extract with antioxidant properties sourced from the Amazonian guayusa plant
Best For Skin Types
All
Addresses
Usage Frequency
Daily
What Is Ilex Guayusa Leaf Extract?
Ilex guayusa leaf extract is derived from the guayusa plant, a species native to the Amazon rainforest. The extract is rich in polyphenols and caffeine, compounds that contribute to its antioxidant profile.
In skincare formulations, this ingredient is typically included for its skin-protecting properties. The antioxidants present may help defend against environmental stressors and free radical damage, which can contribute to premature skin ageing.
How It Works
The antioxidant action of guayusa leaf extract is attributed mainly to its polyphenol content. These compounds work by donating electrons to free radicals, stabilising them and preventing them from damaging skin cells and collagen.
The caffeine present in the extract may also provide mild circulatory benefits, though its role in skincare formulations is primarily secondary to the antioxidant effect.
Clinical Evidence & References
Research specifically on guayusa leaf extract in skincare is limited. Most evidence supporting its use is derived from studies of guayusa as a beverage and general polyphenol research rather than controlled cosmetic studies.
Polyphenols in general are well-documented as antioxidants with skin-protective potential, which provides a reasonable scientific basis for including this ingredient in skincare products. However, more targeted clinical studies on this particular extract would strengthen confidence in its efficacy at typical cosmetic concentrations.
How to Use
This ingredient is most effective as part of a layered skincare routine that includes sun protection, which addresses the primary environmental stressor. It works well alongside other antioxidant ingredients such as vitamin C or niacinamide, and can be used daily in serums, moisturisers or treatment products.
Safety & Precautions
Frequently Asked Questions
From the Clinic
Not sure what your skin actually needs?
Two minutes, a few questions, and we’ll point you at what matters — no guesswork.
Take the skin quizRelated Ingredients
Ilex Aquifolium Leaf Extract
A plant extract with antioxidant properties traditionally used to support skin conditioning
Ilex Aquifolium Leaf Powder
A plant-derived powder that conditions and softens the skin
Ilex Crenata Extract
A plant extract with skin conditioning properties
Ilex Rotunda Extract
Plant extract with potential to support skin resilience and calm inflammatory responses
Ilex Rotunda Leaf Extract
A plant extract with antioxidant properties to help protect skin from environmental stressors
Indigofera Tinctoria Leaf Extract
A natural plant extract traditionally used in cosmetic colouring with skin-conditioning properties
Learn More About Skincare Ingredients
Explore our comprehensive ingredient glossary to understand what's in your products.
Browse All IngredientsShop Our Products
Find professional skincare solutions at Skintique.