Ketoglutaric Acid

Ketoglutaric acid (alpha-ketoglutaric acid or AKG) is a naturally occurring organic compound derived from the tricarboxylic acid cycle—the central metabolic pathway that generates energy in cells. It functions as a metabolite and cofactor, meaning it supports various enzymatic processes within the body and skin.In skincare, ketoglutaric acid is primarily used as a deodorant agent. Beyond this functional role, emerging research suggests it may play a role in cellular health and longevity pathways, though its direct application in cosmetic formulations for anti-ageing benefits is still being …

Ketoglutaric acid operates as a key metabolite in cellular respiration. It acts as a cofactor for enzymes that modify proteins—particularly those involved in ribosomal function and protein accuracy. By supporting these enzymatic processes, it may help cells maintain proper protein folding and synthesis.At the deodorant level, ketoglutaric acid works through chemical neutralisation of odour compounds rather than by blocking sweat production, making it a chemical deodorant rather than an antiperspirant.

If using a product containing ketoglutaric acid, apply as directed on the product label. As with most active ingredients, consistency matters more than frequency. Allow sufficient time to assess tolerance before combining with other potentially irritating actives.

Ketoglutaric acid is generally well-tolerated in cosmetic concentrations. As with any ingredient, patch testing is advisable for those with sensitive skin or known sensitivities to organic acids.