Lipase

Lipase is an enzyme—a type of protein that catalyses chemical reactions—found naturally in human skin, particularly within sebaceous glands and hair follicles. In cosmetic formulations, lipase is used as a skin conditioning agent to support the skin's natural lipid metabolism.The enzyme works by breaking down fats and oils, a process that occurs naturally on the skin's surface. When included in skincare products, lipase may help optimise how the skin processes and manages its own sebum production.

Lipase functions as a catalyst for lipid degradation—essentially breaking down fatty molecules into smaller components. On the skin, this supports the natural turnover of sebum and other lipids that accumulate on the surface.By facilitating this breakdown, lipase may help prevent the buildup of oxidised oils and reduce conditions where excess sebum contributes to congestion or inflammation. The enzyme works in concert with your skin's own biochemical processes rather than replacing them.

Lipase is typically found in very small concentrations within formulations and is generally used as a supporting ingredient rather than a primary active. It works best when combined with other skin conditioning agents and is suitable for inclusion in cleansers, toners, and serums targeting oily or congested skin.

Lipase is generally well-tolerated and safe for topical use. No significant adverse effects have been reported in cosmetic applications.