Skin Conditioning

Liquiritin Apioside

INCI: LIQUIRITIN APIOSIDE

Reviewed by Rosie · Last updated 14 Aug 2026

A liquorice-derived compound traditionally used to support skin conditioning and calm

Best For Skin Types

All, Sensitive, Combination

Addresses

Redness, Sensitivity, Irritation

Usage Frequency

Daily

What Is Liquiritin Apioside?

Liquiritin apioside is a flavonoid compound derived from liquorice root (Glycyrrhiza glabra). It is one of several active constituents found in liquorice extracts, alongside related compounds like liquiritin and isoliquiritin. In skincare formulations, it functions primarily as a skin conditioning agent.

This ingredient has a long history of use in traditional medicine systems, particularly in East Asian skincare and herbal preparations. Its presence in modern skincare products typically comes from liquorice root extracts rather than as an isolated synthetic compound.

How It Works

Liquiritin apioside is believed to work through multiple pathways. As a flavonoid, it possesses antioxidant properties that can help neutralise free radicals and reduce oxidative stress in the skin. Additionally, liquorice-derived compounds have been traditionally used for their ability to calm inflammatory responses in skin tissue.

The ingredient also supports skin's natural moisture retention, contributing to improved skin conditioning and a more supple appearance over time.

Clinical Evidence & References

Research into liquorice extracts containing liquiritin apioside suggests potential benefits for inflammatory skin conditions. Animal studies have indicated that preparations containing this compound may help manage psoriasis-like skin responses, though human clinical data remains limited.

Most evidence for liquiritin apioside comes from traditional use and in vitro or animal studies rather than large-scale human trials. Further research would help clarify its efficacy in skincare formulations at typical concentrations used in cosmetic products.

How to Use

Liquiritin apioside is typically found in serums, moisturisers and calming treatment products. As part of a liquorice extract blend rather than an isolated ingredient, it works well alongside other soothing botanicals. Apply to clean skin as directed by individual product instructions, usually once or twice daily depending on your skin's needs and the product type.

Safety & Precautions

Liquiritin apioside is generally well-tolerated in cosmetic formulations. Those with known liquorice sensitivity should patch test first, though allergic reactions are uncommon.

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