Maclura Cochinchinensis Leaf Prenylflavonoids
INCI: MACLURA COCHINCHINENSIS LEAF PRENYLFLAVONOIDS
Reviewed by Kate · Last updated 14 Aug 2026
Also known as: Maclura Cochinchinensis Leaf Prenyl Flavonoids
A plant-derived prenylflavonoid with potential antioxidant properties
Best For Skin Types
All
Addresses
Usage Frequency
Daily
EWG Safety Score
What Is Maclura Cochinchinensis Leaf Prenylflavonoids?
Maclura cochinchinensis leaf prenylflavonoids are bioactive compounds extracted from the leaves of Maclura cochinchinensis, a plant native to Southeast Asia. Prenylflavonoids are a class of flavonoids—naturally occurring polyphenols found in plants—that have been structurally modified with prenyl groups, which may enhance their stability and skin penetration compared to standard flavonoids.
In skincare formulations, these prenylflavonoids are included primarily for their potential antioxidant activity, which theoretically helps protect skin from oxidative stress and free radical damage.
How It Works
Prenylflavonoids function as antioxidants by donating electrons to neutralise free radicals—unstable molecules that can damage skin cells and accelerate visible ageing. The prenyl side chain on these flavonoids may improve their ability to penetrate the skin and persist longer than non-prenylated flavonoids.
The mechanism is largely understood through in vitro studies and traditional plant use rather than extensive human clinical data specific to skin application.
Clinical Evidence & References
Evidence for Maclura cochinchinensis leaf prenylflavonoids in skincare is limited. Most supporting data comes from laboratory studies examining the antioxidant capacity of the extract, which does not always translate reliably to efficacy when applied topically to human skin.
There is a gap between the theoretical benefits of prenylflavonoids and published clinical trials demonstrating measurable benefits in humans. More research is needed to establish optimal concentrations and skin benefits in real-world use.
Published Research
-
Cosmetics and Toiletries, Accessed February 2023, Website Cosmetics and Toiletries, 2023
-
Molecules, July 2022, ePublication Molecules, 2022
-
Current Topics in Medicinal Chemistry, May 2022, ePublication Current Topics in Medicinal Chemistry, 2022
-
Phytochemistry, July 2021, ePublication Phytochemistry, 2021
How to Use
This ingredient is typically found in serums, essences, and moisturisers. Use as directed by the product formulation, usually once or twice daily. It is generally suitable for layering with other actives, though there is no specific interaction data to report. Start with your product's recommended frequency and adjust based on skin response.
Safety & Precautions
Frequently Asked Questions
From the Clinic
Not sure what your skin actually needs?
Two minutes, a few questions, and we’ll point you at what matters — no guesswork.
Take the skin quizOther forms of Maclura Cochinchinensis Leaf Prenylflavonoids
These appear on ingredients lists under different names but are the same substance. Maclura Cochinchinensis Leaf Prenylflavonoids is the common form.
Related Ingredients
Maclura Cochinchinensis Leaf Prenyl Flavonoids
Subset of flavonoids extracted from the cockspur thorn
Lonicera Caprifolium Flower Extract
Honeysuckle extract with natural preservative properties
Lonicera Japonica Flower Extract
Japanese honeysuckle for purifying protection
Lotus Corniculatus Flower Extract
A botanical extract traditionally used to support skin protection and resilience
Macrocystis Pyrifera (Kelp) Extract
Type of brown seaweed | Contains B vitamins + vitamins A and E
Magnesium Carboxymethyl Beta-Glucan
Helps soothe a compromised skin barrier
Learn More About Skincare Ingredients
Explore our comprehensive ingredient glossary to understand what's in your products.
Browse All IngredientsShop Our Products
Find professional skincare solutions at Skintique.