Mirabilis Jalapa Extract
INCI: MIRABILIS JALAPA EXTRACT
Reviewed by Emma · Last updated 14 Aug 2026
A plant extract traditionally used to support skin hydration and calm inflammatory responses
Best For Skin Types
Sensitive, Dry, All
Addresses
Usage Frequency
Daily
What Is Mirabilis Jalapa Extract?
Mirabilis jalapa extract is derived from the leaves and roots of the four o'clock plant, a species native to tropical regions and used in traditional medicine across Central and South America and Brazil. The extract is prepared through maceration and contains compounds believed to interact with the skin's inflammatory and immune responses.
In skincare formulations, it functions as a skin conditioning and protective agent, primarily noted for its potential anti-inflammatory and antihistamine properties. It is typically incorporated into moisturisers and treatment products intended for reactive or sensitised skin.
How It Works
Mirabilis jalapa extract appears to work through multiple mechanisms. Research indicates it can inhibit histamine release from mast cells, immune cells involved in allergic and inflammatory skin responses. By modulating these pathways, the extract may reduce the cascade of inflammation that leads to redness, itching and discomfort.
Additionally, when incorporated into moisturisers, anti-inflammatory ingredients like this extract seem to support the skin's ability to retain hydration more effectively. This dual action of calming inflammatory activity whilst enhancing hydration may be particularly beneficial for compromised or reactive skin states.
Clinical Evidence & References
Preclinical studies demonstrate that aqueous and ethanolic extracts of Mirabilis jalapa show dose-dependent anti-inflammatory activity in animal models, including inhibition of paw oedema and mast cell degranulation. The extract also demonstrates non-competitive inhibition of histamine-induced responses in isolated tissue preparations, lending mechanistic support to traditional uses in allergic and inflammatory conditions.
A clinical trial in adult patients with mild-to-moderate atopic dermatitis found that moisturisers formulated with anti-inflammatory ingredients produced significant improvements in skin hydration over 14 days compared to control moisturisers. However, evidence specifically isolating Mirabilis jalapa's efficacy in human skin is currently limited, and further clinical studies would help establish its efficacy and optimal concentrations in skincare products.
Published Research
How to Use
Mirabilis jalapa extract is typically used as part of a moisturiser or treatment serum applied to clean skin. For reactive or sensitised skin, begin with daily application and observe how your skin responds over one to two weeks. If you have very compromised skin or active dermatitis, introduce it gradually and consider patch testing first. It works well as part of a layered hydration routine and can be combined with other soothing or barrier-support ingredients.
Safety & Precautions
Frequently Asked Questions
From the Clinic
Not sure what your skin actually needs?
Two minutes, a few questions, and we’ll point you at what matters — no guesswork.
Take the skin quizOther forms of Mirabilis Jalapa Extract
These appear on ingredients lists under different names but are the same substance. Mirabilis Jalapa Extract is the common form.
Related Ingredients
Mirabilis Jalapa Callus Extract
A plant-derived extract that supports skin's natural protective barrier
Mirabilis Jalapa Seed Extract
Plant-derived extract traditionally used to support skin's natural protective barrier
Milt Extract
A polynucleotide extract derived from salmon milt that conditions and supports skin resilience
Mineral Salts
Mineral-rich salts that may support skin conditioning and barrier function
Molasses
A natural humectant derived from sugarcane processing with skin-conditioning properties
Molasses Extract
A fermentation byproduct with antioxidant and skin-conditioning properties
Learn More About Skincare Ingredients
Explore our comprehensive ingredient glossary to understand what's in your products.
Browse All IngredientsShop Our Products
Find professional skincare solutions at Skintique.