Nicotinic Acid Adenine Dinucleotide Phosphate

Nicotinic acid adenine dinucleotide phosphate (NADP+) is a coenzyme derived from niacin (vitamin B3). It exists naturally in all living cells and plays a central role in cellular energy production and metabolic processes. In skincare formulations, it functions as a skin conditioner and protectant.This ingredient works at a biochemical level to support the skin's natural defence mechanisms, particularly in response to environmental stressors such as UV exposure. Its role centres on regulating intracellular signalling pathways that influence how skin cells respond to damage.

When skin is exposed to UV radiation, intracellular calcium signals are triggered in a cascade that generates several messenger molecules, including NADP+. This ingredient acts as one of these messengers, influencing how keratinocytes (skin cells) produce inflammatory compounds in response to UV damage.By modulating these signalling pathways, NADP+ helps coordinate the skin's stress response at a molecular level. It also supports the cell's redox balance—essentially the ratio of oxidising and reducing molecules—which is fundamental to protecting against oxidative damage.

This ingredient is typically found in serums, moisturisers, and protective skincare products. Since it functions at a cellular level rather than providing surface-level benefits, consistent use over time is more relevant than occasional application. Use as directed by the product instructions, typically once or twice daily depending on the formulation.

NADP+ is well-tolerated and derived from a B vitamin naturally present in the body. No significant adverse effects have been reported in cosmetic use.