Nicotinoyl Dipeptide-22

Nicotinoyl Dipeptide-22 is a synthetic peptide derived from niacinamide, a well-established skincare ingredient. It belongs to a class of niacinamide derivatives engineered to target skin pigmentation through a different mechanism than traditional tyrosinase inhibitors.The ingredient works primarily as a skin conditioning agent, with research suggesting it may help reduce the appearance of uneven tone and pigmented spots when incorporated into topical formulations.

Rather than directly inhibiting tyrosinase (the enzyme that produces melanin), Nicotinoyl Dipeptide-22 appears to work by suppressing the transfer of melanosomes — the pigment-containing structures within melanocytes — to surrounding skin cells. This indirect mechanism may help reduce visible pigmentation without disrupting normal cellular function.The ingredient also retains antioxidant properties, which may offer additional protective benefits to the skin barrier.

Nicotinoyl Dipeptide-22 is typically found in serums, essences, and targeted treatment products. Apply to cleansed skin as directed by the product formulation. It can generally be incorporated into morning and evening routines, though patch testing is advisable if you have sensitive skin or are using multiple active ingredients.

Research suggests this ingredient is well tolerated at typical use concentrations, with no evidence of irritation or sensitisation in human trials. It is not known to cause phototoxicity.