Peptides

Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-9

INCI: NICOTIANA BENTHAMIANA HEXAPEPTIDE-40 SH-POLYPEPTIDE-9

Reviewed by Kate · Last updated 14 Aug 2026

Also known as: Nicotiana Benthamiana Hexapeptide-40 Sh-polypeptide-9

A plant-derived peptide with potential applications in addressing skin ageing

Best For Skin Types

All, Dry, Mature, Sensitive

Addresses

Fine lines, Dryness, Skin firmness

Usage Frequency

Daily

What Is Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-9?

Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-9 is a peptide derived from Nicotiana benthamiana, a plant species commonly used in biotechnology for producing recombinant proteins. This ingredient is created through bioengineering techniques that allow plants to synthesise specific peptide sequences for use in cosmetic formulations.

In skincare, this peptide is primarily used for its conditioning properties. Peptides function by mimicking or supporting natural protein structures in the skin, potentially helping to maintain skin firmness and smoothness.

How It Works

This peptide is thought to work by signalling to skin cells to support collagen and structural protein production. Peptides are relatively small protein fragments that can penetrate the outer skin layers more effectively than larger proteins, allowing them to interact with skin cells and potentially influence their behaviour.

Research into related peptides suggests they may help mitigate some effects of photoaging (sun damage) by promoting cellular repair processes, though the specific mechanisms for this particular peptide require further investigation.

Clinical Evidence & References

The research base for this specific ingredient is limited. Available studies have focused on using Nicotiana benthamiana as a production platform for growth factors like acidic fibroblast growth factor (aFGF), which has anti-ageing potential. However, direct clinical evidence demonstrating the efficacy of Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-9 in skincare products remains sparse.

While peptides as a class show promise for supporting skin structure and resilience, more targeted research is needed to confirm the specific benefits and optimal concentrations of this ingredient in cosmetic formulations.

How to Use

This ingredient is typically found in serums, moisturisers and targeted treatments. Apply to clean skin as directed by the product instructions. It works well in layered routines and pairs effectively with other conditioning and anti-ageing ingredients. As with any peptide product, consistent use over time is generally recommended to observe potential benefits.

Safety & Precautions

This ingredient is generally well-tolerated in cosmetic formulations. As with any peptide product, perform a patch test if you have particularly sensitive skin or known sensitivities to plant-derived ingredients.

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