Peptides

Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-86

INCI: NICOTIANA BENTHAMIANA HEXAPEPTIDE-40 SH-POLYPEPTIDE-86

Reviewed by Rosie · Last updated 14 Aug 2026

Also known as: Nicotiana Benthamiana Hexapeptide-40 Sh-polypeptide-86

A plant-derived peptide complex with emerging research into skin resilience

Best For Skin Types

All, Dry, Mature

Addresses

Dryness, Skin texture, Barrier support

Usage Frequency

Daily

What Is Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-86?

Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-86 is a peptide derived from Nicotiana benthamiana, a plant species used in biotechnology research. This ingredient is produced through recombinant protein expression — a technique that uses plant cells to manufacture specific peptide sequences designed to support skin function.

In cosmetic formulations, this ingredient is primarily used as a conditioning agent, helping to improve the texture and feel of skincare products. The peptide structure allows it to interact with skin at a molecular level, though its specific mechanisms in skincare remain an area of active research.

How It Works

Peptides like this one are short chains of amino acids that can penetrate or interact with the outer layers of skin. Their small molecular size allows them to potentially influence skin cells, though the depth and extent of penetration varies depending on the specific peptide structure and formulation.

Research into Nicotiana benthamiana-derived proteins suggests potential support for skin resilience and photoprotection, though most evidence remains preclinical or investigational. The exact mechanism by which this particular polypeptide works in skincare products requires further clinical validation.

Clinical Evidence & References

Research into proteins derived from Nicotiana benthamiana has explored their potential role in skin protection, particularly around growth factors and resilience to environmental stress. However, most studies to date have focused on the plant expression system itself rather than direct application to human skin.

Evidence specific to this ingredient's efficacy in cosmetic formulations is limited. Whilst the underlying science of peptides in skincare is well-established, clinical data demonstrating the particular benefits of this polypeptide in real-world use remains sparse. Further human studies would help clarify its practical benefits.

How to Use

This ingredient is typically found in leave-on skincare products rather than rinse-off formulations. Use as directed by the product instructions, generally as part of your regular skincare routine. It works well in layered routines and does not typically require special application techniques.

Safety & Precautions

Generally well-tolerated in cosmetic products. As with any peptide-containing product, discontinue use if signs of irritation develop, and perform a patch test if you have sensitive skin.

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