Peptides

Nicotiana Benthamiana Rh-Oligopeptide-1

INCI: NICOTIANA BENTHAMIANA RH-OLIGOPEPTIDE-1

Reviewed by Daisy · Last updated 2 Jun 2026

Also known as: Nicotiana Benthamiana Rh-oligopeptide-1

A plant-derived peptide designed to support skin's natural protective functions

Best For Skin Types

All, Sensitive

Addresses

Sensitivity, Barrier repair

Usage Frequency

Daily

What Is Nicotiana Benthamiana Rh-Oligopeptide-1?

Nicotiana Benthamiana Rh-Oligopeptide-1 is a peptide derived from Nicotiana benthamiana, a plant species related to tobacco. In cosmetic formulation, it functions as a skin-protecting ingredient, working to maintain and support the skin's natural defence mechanisms.

Peptides are short chains of amino acids that can communicate with skin cells. This particular peptide is classified as a skin protectant, meaning its primary role is to help shield the skin from environmental stressors and support overall skin resilience.

How It Works

Peptides work by interacting with skin cells at a molecular level, essentially 'communicating' instructions that prompt the skin to strengthen its defences. Nicotiana Benthamiana Rh-Oligopeptide-1 is designed to activate or support the skin's protective pathways, helping it maintain its barrier function and resist environmental damage.

Rather than providing hydration or exfoliation, this ingredient works preventatively — supporting the skin's own capacity to protect itself from oxidative stress, pollution, and other external challenges.

Clinical Evidence & References

Research into Nicotiana benthamiana as a production system has demonstrated its ability to generate recombinant proteins with potential cosmetic applications, including growth factors associated with skin health and anti-ageing benefit. However, direct clinical evidence specifically validating this oligopeptide's efficacy in finished skincare products remains limited.

The ingredient appears in skincare formulations marketed for protective purposes, but large-scale clinical trials demonstrating measurable improvements in skin barrier function or resilience are not widely published. Further research would strengthen understanding of its real-world benefits when used topically.

How to Use

This ingredient is typically found in serums, moisturisers, and barrier-support products. Use it as part of your regular routine — it works best when applied consistently, ideally to clean skin before heavier products like oils or occlusives. No special application technique is required; simply apply and allow it to absorb.

Safety & Precautions

Generally considered well-tolerated in skincare formulations. As with any peptide ingredient, those with known sensitivities to plant-derived proteins should patch test first.

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