Peptides

Nicotiana Benthamiana Octapeptide-30 Sh-Oligopeptide-2

Reviewed by Kate · Last updated 20 Jul 2026

A plant-derived peptide complex studied for its potential role in supporting skin resilience

Best For Skin Types

All, Dry, Mature

Addresses

Fine lines, Hydration, Skin firmness

Usage Frequency

Daily

What Is Nicotiana Benthamiana Octapeptide-30 Sh-Oligopeptide-2?

Nicotiana Benthamiana Octapeptide-30 Sh-Oligopeptide-2 is a peptide derived from the Nicotiana benthamiana plant (a relative of tobacco). This ingredient is created through biotechnology, where the plant is used as a production system to generate specific peptide sequences that may benefit skin.

Peptides are short chains of amino acids. In skincare, they are used because they can penetrate the outer layers of skin and may influence cellular processes. This particular peptide is included in formulations intended to address visible signs of ageing and support skin hydration.

How It Works

This peptide is thought to work by interacting with skin cells in a way that may stimulate the production or activity of fibroblasts—the cells responsible for producing collagen and elastin. If this mechanism holds true in topical application, it could theoretically support skin structure and resilience over time.

However, the evidence for topical efficacy in humans remains limited. Most research has focused on the production method and laboratory-based cellular responses rather than proven effects on living human skin.

Clinical Evidence & References

Research exists on the production and characterisation of this peptide in plant systems, and laboratory studies suggest potential activity in fibroblast-related pathways. However, robust clinical evidence demonstrating visible anti-ageing benefits in human skin is currently limited.

The ingredient appears in skincare products marketed for anti-ageing and hydration, but independent human studies validating these claims are not widely available. More research would strengthen confidence in its efficacy at typical cosmetic concentrations.

How to Use

This ingredient is typically found in serums, creams and moisturisers as part of a broader formulation. For best results, use consistently as part of your daily routine. Like most peptide-containing products, results develop gradually over weeks of regular use rather than immediately.

Safety & Precautions

This ingredient is generally well-tolerated in cosmetic formulations. As with any skincare product, patch test before widespread use if you have sensitive or reactive skin.

Frequently Asked Questions

From the Clinic

Not sure what your skin actually needs?

Two minutes, a few questions, and we’ll point you at what matters — no guesswork.

Take the skin quiz

Learn More About Skincare Ingredients

Explore our comprehensive ingredient glossary to understand what's in your products.

Browse All Ingredients

Authorised Stockist

Official UK retailer

Tracked Delivery

Free UK shipping over £50

5 Star Rating

Trusted by thousands

Expert Advice

Free consultations