Addresses
EWG Safety Score
What Is sh-Oligopeptide-2?
Sh-Oligopeptide-2 is a single-chain recombinant human peptide, also known as Insulin-like Growth Factor 1 (IGF-1). It belongs to the group of ingredients known as Growth Factors, similar to Epidermal Growth Factor (EGF). Consisting of 70 amino acids, it is primarily claimed to stimulate cell proliferation and accelerate wound healing. Studies suggest that it works synergistically with EGF to promote keratinocyte (skin cell) proliferation. In cosmetic formulations, it functions as a skin conditioning and skin protecting agent, helping to maintain the skin's overall health and barrier function. As of the current review, has not yet assigned a rating to this ingredient, noting that research is ongoing to provide the most accurate information.
Clinical Evidence & References
Published Research
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Krane, Jeffrey F., et al. "Synergistic effects of epidermal growth factor (EGF) and insulin-like growth factor I/somatomedin C (IGF-I) on keratinocyte proliferation may be mediated by IGF-I transmodulation of the EGF receptor." Journal of investigative dermatology 96.4 (1991): 419-424 [https://pubmed.ncbi.nlm.nih.gov/1848876/]
Frequently Asked Questions
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Sh-Oligopeptide-10
A peptide fragment that supports skin conditioning and structural integrity
Sh-Oligopeptide-102 Sp
A peptide that may help regulate skin's inflammatory and sensory responses
Sh-Oligopeptide-14
A peptide that conditions skin and supports its natural moisture retention
Sh-Oligopeptide-4
A peptide fragment that supports skin conditioning and structural integrity
Sh-Oligopeptide-78
A peptide-derived conditioning agent with dual benefits for hair and skin
Sh-Oligopeptide-9
A peptide ingredient that supports skin hydration and structural integrity
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