Best For Skin Types
All, Sensitive
Addresses
Usage Frequency
Daily
What Is Sh-Oligopeptide-102 Sp?
Sh-Oligopeptide-102 Sp is a synthetic peptide derived from substance P (SP), a neuropeptide naturally present in the skin. Peptides are short chains of amino acids that can communicate with skin cells to influence their behaviour. This ingredient is classified as a skin protectant and conditioner.
The ingredient works by engaging with the neurovascular and neuroimmune systems in skin—essentially the network of nerves, immune cells, and blood vessels that maintain skin health. By modulating how these systems interact, it may help reduce inflammatory responses and support skin barrier function.
How It Works
Sh-Oligopeptide-102 Sp influences a pathway called neurogenic inflammation. Normally, sensory nerves in the skin release neuropeptides (including substance P) that signal mast cells—immune cells in the dermis—to release inflammatory mediators. This process, whilst sometimes protective, can spiral into excessive redness, irritation, and sensitivity.
By interacting with this neuro-immune axis, this peptide appears to moderate mast cell activation and the inflammatory cascade that follows. This may be particularly relevant in conditions where nerve-immune signalling is overactive, such as inflammatory skin disorders or reactive skin types.
Clinical Evidence & References
Research indicates that dysregulation of neurogenic inflammation (and the substance P pathway) contributes to conditions like psoriasis and other inflammatory skin disorders. Studies show that mast cell degranulation and sensory nerve activation play central roles in skin inflammation and even microvascular dysfunction in metabolic conditions.
However, evidence specifically for Sh-Oligopeptide-102 Sp in human skin remains limited. The ingredient's theoretical benefit is well-grounded in understanding of skin neurobiology, but robust clinical trials demonstrating efficacy in cosmetic formulations are not extensively published in accessible literature. It appears in skincare products marketed for sensitive and reactive skin, though independent clinical validation would strengthen claims.
How to Use
This ingredient is typically found in serums, moisturisers, and targeted treatment products. It is often used daily as part of a regular skincare routine. As with all active ingredients, introduce it gradually if you have very reactive skin, and pair it with a stable routine that includes a good sunscreen during the day.
Safety & Precautions
Frequently Asked Questions
From the Clinic
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