Peptides

Sh-Oligopeptide-10

INCI: SH-OLIGOPEPTIDE-10

Reviewed by Kate · Last updated 14 Aug 2026

A peptide fragment that supports skin conditioning and structural integrity

Best For Skin Types

All, Dry, Mature, Sensitive

Addresses

Fine lines, Dryness, Hydration

Usage Frequency

Daily

What Is Sh-Oligopeptide-10?

Sh-Oligopeptide-10 is a short-chain peptide derived from a natural protein source. Peptides are small fragments of amino acids, and this particular oligopeptide is used in skincare formulations primarily for its skin conditioning properties.

The ingredient functions as a humectant and skin conditioning agent, helping to support the skin's natural moisture retention and overall texture. It is typically incorporated into serums, moisturisers, and treatment products at low concentrations.

How It Works

Oligopeptides work primarily through hydration and film-forming properties. When applied to the skin surface, they can absorb and bind moisture, helping to create a more plump and supple appearance. This mechanism supports the skin's barrier function and may help reduce transepidermal water loss.

The conditioning effect is thought to improve skin feel and appearance by enhancing hydration at the stratum corneum (the outermost layer of skin). This is particularly relevant as skin naturally loses moisture and structural proteins with age.

Clinical Evidence & References

Research into skin ageing demonstrates that loss of hydration and structural proteins contributes to visible signs of ageing, including fine lines and loss of elasticity. Peptides in general are recognised as useful conditioning agents that support skin hydration and texture.

However, specific clinical data on Sh-Oligopeptide-10 is limited in published literature. The ingredient is primarily used for its established skin conditioning and hydrating properties rather than for dramatic structural changes. More targeted research would help establish its precise efficacy in anti-ageing or other specialised applications.

How to Use

This ingredient works well in both morning and evening routines as part of a hydrating serum or moisturiser. It is generally compatible with most other skincare actives, though as with any new product, introduce it gradually if you have sensitive skin. Apply to damp skin to maximise its hydrating effect.

Safety & Precautions

Sh-Oligopeptide-10 is generally well-tolerated and suitable for most skin types. Peptides have a strong safety history in cosmetics and rarely cause irritation or allergic reactions.

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