Nicotinoyl Dipeptide-23

Nicotinoyl Dipeptide-23 is a synthetic peptide—a short chain of amino acids—combined with niacinamide (vitamin B3). Peptides are valued in skincare for their potential to support skin structure and function, as they're recognised by the skin as signalling molecules.This ingredient is primarily used as a skin conditioning agent. Its niacinamide component contributes anti-inflammatory and skin-barrier-supportive properties that are well-documented in skincare research.

The peptide portion of this molecule works by signalling to skin cells, potentially encouraging them to maintain their natural repair and support systems. Niacinamide (B3) strengthens the skin barrier by supporting ceramide production and reducing transepidermal water loss.Together, these components work on both the structural and signalling level—the peptide delivers a message, whilst niacinamide provides tangible barrier support.

This ingredient is typically found in serums, moisturisers, and treatment products. Use it twice daily as part of your regular routine. It layers well with other actives and is not known to conflict with common skincare ingredients. Apply to clean skin and follow with appropriate moisturiser or sunscreen as needed.

Nicotinoyl Dipeptide-23 is generally well-tolerated. Those sensitive to niacinamide may experience mild irritation, though concentrations in skincare are typically modest.