Peptides

Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76

INCI: NICOTIANA BENTHAMIANA HEXAPEPTIDE-40 SH-POLYPEPTIDE-76

Reviewed by Rosie · Last updated 2 Jun 2026

Also known as: Nicotiana Benthamiana Hexapeptide-40 Sh-polypeptide-76

A plant-derived peptide complex designed to support skin conditioning and resilience

Best For Skin Types

All

Addresses

Dryness, Dehydration, Loss of elasticity

Usage Frequency

Daily

What Is Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76?

Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76 is a peptide derived from the Nicotiana benthamiana plant, a species commonly used in biotechnology research and ingredient development. This ingredient is produced through bioengineering techniques that allow plants to express specific protein sequences, which are then isolated and purified for use in skincare formulations.

As a skin conditioning agent, this peptide works at a molecular level to support the skin's structural integrity and appearance. Peptides are short chains of amino acids that can penetrate the skin's outer layers and communicate with cells to encourage beneficial responses.

How It Works

This peptide functions by signalling to skin cells through amino acid sequences. When applied topically, peptides can penetrate the stratum corneum and interact with fibroblasts and other skin cells, potentially stimulating them to maintain or improve their normal functions.

The specific hexapeptide and polypeptide sequences in this ingredient are designed to encourage skin conditioning responses. Research suggests that plant-derived growth factors and peptides may help support the skin's natural repair and maintenance processes, though the precise mechanisms in cosmetic concentrations require further investigation.

Clinical Evidence & References

The research foundation for this ingredient centres on the plant's ability to produce recombinant human growth factors, particularly acidic fibroblast growth factor (aFGF). Studies demonstrate that Nicotiana benthamiana can effectively express and yield functional recombinant proteins with potential relevance to skin health and photoaging prevention.

However, whilst the botanical source shows promise for producing bioactive compounds, direct clinical evidence demonstrating efficacy of this specific peptide in finished skincare products remains limited. The ingredient's conditioning properties are supported by its peptide chemistry, but comprehensive human studies at typical cosmetic concentrations would strengthen confidence in its practical benefits.

How to Use

This ingredient is typically found in serums, moisturisers and treatment products. Apply to clean skin as part of your regular routine. Since it works as a conditioning agent rather than an active treatment, consistency over time is more important than frequency. Pair with complementary ingredients suited to your skin's needs, such as hydrators or antioxidants.

Safety & Precautions

This ingredient is generally well-tolerated in skincare formulations. As with any new ingredient, perform a patch test if you have particularly sensitive skin or known sensitivities to peptides.

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