Peptides

Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-2

INCI: NICOTIANA BENTHAMIANA HEXAPEPTIDE-40 SH-POLYPEPTIDE-2

Reviewed by Kate · Last updated 2 Jun 2026

Also known as: Nicotiana Benthamiana Hexapeptide-40 Sh-polypeptide-2

A plant-derived peptide with potential benefits for skin conditioning and resilience

Best For Skin Types

All, Dry, Mature

Addresses

Dryness, Hydration, Barrier repair

Usage Frequency

Daily

What Is Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-2?

Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-2 is a peptide derived from Nicotiana benthamiana, a plant species commonly used in biotechnology for recombinant protein production. This ingredient is engineered to function as a skin and hair conditioning agent, working at the molecular level to support skin structure and hydration.

The ingredient belongs to the broader peptide family in skincare, which are short chains of amino acids designed to interact with skin proteins and support various aspects of skin health and appearance.

How It Works

Peptides function by penetrating or adhering to the outer layers of skin, where they can interact with existing skin proteins and support natural processes. In this case, the hexapeptide structure is designed to optimise skin conditioning effects through molecular signalling or direct hydration support.

The ingredient's origin in plant biotechnology means it is produced through controlled expression systems, ensuring consistency and purity in formulation.

Clinical Evidence & References

Research into Nicotiana benthamiana as a biotechnology platform has focused on its ability to produce recombinant human proteins with potential skincare applications, including growth factors involved in skin health. However, specific clinical studies directly demonstrating the efficacy of this particular hexapeptide-polypeptide complex in human skin are limited in the available literature.

The ingredient shows promise based on its peptide structure and conditioning properties, but further human studies would help establish clear efficacy profiles for specific skin concerns.

How to Use

This ingredient is typically incorporated into serums, moisturisers, and leave-in hair products. As with any peptide-based ingredient, consistent use over several weeks is recommended to observe conditioning benefits. It works well in formulations alongside other hydrating and supporting ingredients, though no specific incompatibilities are documented.

Safety & Precautions

Generally well-tolerated in cosmetic formulations. As a peptide derived from plant biotechnology, it is unlikely to trigger common sensitivities, though patch testing is advisable for those with known peptide sensitivities.

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