Niacinamide/Yeast Polypeptide

This ingredient combines niacinamide (vitamin B3) with yeast polypeptides—small proteins derived from yeast fermentation. Niacinamide is a water-soluble vitamin that has been studied for its role in skin health, whilst yeast polypeptides are included for their skin-conditioning properties. Together, they form a hybrid ingredient designed to support skin barrier function and overall skin condition.The yeast component is typically produced through fermentation, a process that breaks down yeast cell walls to create smaller peptide fragments. These fragments are believed to have mild humectant …

Niacinamide is thought to influence ceramide and fatty acid synthesis in the skin, supporting the structural integrity of the stratum corneum (the skin's outermost layer). This may help regulate sebum production and reduce water loss. The yeast polypeptides work alongside this by conditioning the skin surface, enhancing softness and providing a protective film.Because both components are relatively gentle, they work together to provide foundational skin support rather than exerting dramatic effects. The polypeptides may also have mild antioxidant properties, though research on yeast-derived…

This ingredient is suitable for daily use in serums, moisturisers, and essences. Because both niacinamide and yeast polypeptides are gentle, there is no need to introduce them slowly unless you have particularly reactive skin. Apply to clean, damp skin before heavier creams or oils to allow for proper absorption. It pairs well with other hydrating and barrier-support ingredients.

Both niacinamide and yeast polypeptides are generally well-tolerated across skin types. Very rarely, niacinamide may cause mild flushing in sensitive individuals. Those with yeast sensitivities should patch-test first, though yeast polypeptides are unlikely to trigger typical food-related allergies.