Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-47
INCI: NICOTIANA BENTHAMIANA HEXAPEPTIDE-40 SH-POLYPEPTIDE-47
Reviewed by Daisy · Last updated 2 Jun 2026
Also known as: Nicotiana Benthamiana Hexapeptide-40 Sh-polypeptide-47
A plant-derived peptide designed to support skin conditioning and resilience
Best For Skin Types
All
Addresses
Usage Frequency
Daily
What Is Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-47?
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-47 is a peptide derived from Nicotiana benthamiana, a plant species commonly used in biotechnology for producing recombinant proteins. This ingredient is created through advanced expression systems that allow plants to produce human-relevant peptides at scale, offering a biotechnological approach to skincare.
In formulations, this peptide functions as a skin conditioning agent, working to support the skin's structural integrity and overall condition. It represents a newer class of biotech-derived ingredients designed to interact with skin at a molecular level.
How It Works
This peptide is produced using plant-based biotechnology, where Nicotiana benthamiana is used as a bioreactor to express human peptide sequences. Once isolated and purified, the peptide is incorporated into skincare formulations where it can interact with skin cells.
As a short-chain peptide, it is designed to penetrate the outer layers of skin and support cellular communication and structural proteins. The specific mechanism by which this particular peptide influences skin behaviour is still being characterised, though peptides in general are believed to support collagen production and skin firmness through signalling pathways.
Clinical Evidence & References
Research into Nicotiana benthamiana as a production platform has focused on its capacity to express recombinant proteins efficiently—particularly acidic fibroblast growth factor, a protein relevant to skin renewal. Studies suggest the plant system can produce stable, bioactive peptides, though direct clinical evidence for this specific hexapeptide-polypeptide combination in human skin is limited.
The ingredient sits at the intersection of peptide science and plant biotechnology. Whilst peptides as a class have established benefits for skin conditioning and structural support, individual peptides require their own evidence base. Further human studies would help clarify the specific skin benefits of this formulation.
Published Research
How to Use
This ingredient is typically found in serums, creams, and treatments designed for skin conditioning. Use as directed on product packaging. Since peptide ingredients work best as part of a consistent routine, daily application is common. There is no evidence that higher concentrations necessarily improve results, so follow the manufacturer's guidance.
Safety & Precautions
Frequently Asked Questions
From the Clinic
Not sure what your skin actually needs?
Two minutes, a few questions, and we’ll point you at what matters — no guesswork.
Take the skin quizRelated Ingredients
Niacinamide/Yeast Polypeptide
A multifunctional combination pairing niacinamide with yeast-derived peptides for skin conditioning
Nicotiana Benthamiana Hexapeptide-40 sh-Oligopeptide-1
Plant-derived EGF-like peptide for skin renewal
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-2
A plant-derived peptide with potential benefits for skin conditioning and resilience
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-6
A plant-derived peptide designed to support skin conditioning and firmness
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76
A plant-derived peptide complex designed to support skin conditioning and resilience
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-86
A plant-derived peptide complex with emerging research into skin resilience
Learn More About Skincare Ingredients
Explore our comprehensive ingredient glossary to understand what's in your products.
Browse All IngredientsShop Our Products
Find professional skincare solutions at Skintique.