Peptides

Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-47

INCI: NICOTIANA BENTHAMIANA HEXAPEPTIDE-40 SH-POLYPEPTIDE-47

Reviewed by Daisy · Last updated 2 Jun 2026

Also known as: Nicotiana Benthamiana Hexapeptide-40 Sh-polypeptide-47

A plant-derived peptide designed to support skin conditioning and resilience

Best For Skin Types

All

Addresses

Fine lines, Firmness, Skin resilience

Usage Frequency

Daily

What Is Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-47?

Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-47 is a peptide derived from Nicotiana benthamiana, a plant species commonly used in biotechnology for producing recombinant proteins. This ingredient is created through advanced expression systems that allow plants to produce human-relevant peptides at scale, offering a biotechnological approach to skincare.

In formulations, this peptide functions as a skin conditioning agent, working to support the skin's structural integrity and overall condition. It represents a newer class of biotech-derived ingredients designed to interact with skin at a molecular level.

How It Works

This peptide is produced using plant-based biotechnology, where Nicotiana benthamiana is used as a bioreactor to express human peptide sequences. Once isolated and purified, the peptide is incorporated into skincare formulations where it can interact with skin cells.

As a short-chain peptide, it is designed to penetrate the outer layers of skin and support cellular communication and structural proteins. The specific mechanism by which this particular peptide influences skin behaviour is still being characterised, though peptides in general are believed to support collagen production and skin firmness through signalling pathways.

Clinical Evidence & References

Research into Nicotiana benthamiana as a production platform has focused on its capacity to express recombinant proteins efficiently—particularly acidic fibroblast growth factor, a protein relevant to skin renewal. Studies suggest the plant system can produce stable, bioactive peptides, though direct clinical evidence for this specific hexapeptide-polypeptide combination in human skin is limited.

The ingredient sits at the intersection of peptide science and plant biotechnology. Whilst peptides as a class have established benefits for skin conditioning and structural support, individual peptides require their own evidence base. Further human studies would help clarify the specific skin benefits of this formulation.

How to Use

This ingredient is typically found in serums, creams, and treatments designed for skin conditioning. Use as directed on product packaging. Since peptide ingredients work best as part of a consistent routine, daily application is common. There is no evidence that higher concentrations necessarily improve results, so follow the manufacturer's guidance.

Safety & Precautions

This peptide is generally well-tolerated in skincare formulations. As with any new ingredient, perform a patch test if you have sensitive skin or a history of adverse reactions to peptide-based products.

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