Peptides

Myristoyl Tripeptide-4

INCI: MYRISTOYL TRIPEPTIDE-4

Reviewed by Kate · Last updated 14 Aug 2026

Also known as: Myristoyl Tripeptide-4

A peptide that conditions skin and may support natural firmness signals

Best For Skin Types

All, Dry, Mature, Combination

Addresses

Fine lines, Hydration, Firmness

Usage Frequency

Daily

What Is Myristoyl Tripeptide-4?

Myristoyl Tripeptide-4 is a synthetic peptide—a short chain of amino acids—created by attaching a myristic acid (a fatty acid) to a three-amino-acid sequence. This modification helps the peptide penetrate and remain stable in skincare formulations.

As a skin conditioning agent, it functions primarily to soften and smooth the skin surface. Some peptides in this category are studied for their potential to communicate with skin cells in ways that may influence natural skin firmness and elasticity, though individual peptides vary considerably in their activity.

How It Works

Myristoyl Tripeptide-4 works as a conditioning agent by coating the skin and reducing water loss, which creates an immediately smoother feel. The myristic acid component enhances penetration, allowing the peptide to interact with skin cells more effectively than an unmodified peptide might.

Some peptides are thought to mimic or enhance natural signalling pathways related to skin structure and firmness, though the specific mechanism for this particular tripeptide is not widely published in independent peer-reviewed research.

Clinical Evidence & References

Published independent clinical data on Myristoyl Tripeptide-4 is limited. Most evidence comes from manufacturer or supplier-funded studies, which typically show improvements in skin smoothness and hydration when used in formulations. These studies generally use subjective assessment methods (such as volunteer feedback) rather than instrumental measurement.

The ingredient belongs to a broader class of peptides with established skin-conditioning properties, but claims about firming or elasticity benefits should be considered preliminary without robust, published clinical validation.

How to Use

Use as directed by the product formulation—typically as part of a daily or twice-daily routine in serums, moisturisers, or targeted treatments. Apply to clean skin before heavier products. Because peptides work best in a stable environment, store formulations away from direct sunlight and heat, and use within the product's recommended timeframe.

Safety & Precautions

Myristoyl Tripeptide-4 is generally well-tolerated and suitable for most skin types. No significant adverse reactions have been widely reported, though individual sensitivity is always possible.

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