Peptides

Myristoyl Tetrapeptide-13

INCI: MYRISTOYL TETRAPEPTIDE-13

Reviewed by Rosie · Last updated 14 Aug 2026

Also known as: Myristoyl Tetrapeptide-13

A peptide derivative used primarily for skin conditioning in cosmetic formulations

Best For Skin Types

All

Addresses

Hydration, Skin texture

Usage Frequency

Daily

What Is Myristoyl Tetrapeptide-13?

Myristoyl Tetrapeptide-13 is a synthetic peptide — a short chain of amino acids — that has been chemically modified with a myristic acid (a fatty acid) attached to its structure. This modification is designed to improve how the ingredient behaves in skincare formulations and how it interacts with the skin.

In cosmetic products, it functions as a skin conditioning agent, meaning it is intended to help maintain or improve the texture and feel of the skin. Peptides are popular in skincare because they are believed to communicate with skin cells, though the specific biological activity of individual peptides varies considerably.

How It Works

The ingredient works through skin conditioning properties. The fatty acid component (myristic acid) helps it penetrate or bind to the skin, whilst the peptide portion may interact with skin cells. The exact mechanisms by which this specific peptide communicates with skin cells remain not fully characterised in publicly available research.

Its primary role in skincare is functional — helping to keep formulations stable and ensuring they feel pleasant on application — rather than providing a specific targeted benefit like exfoliation or sun protection.

Clinical Evidence & References

Published clinical evidence specific to Myristoyl Tetrapeptide-13 is limited. Most information about peptide ingredients in general suggests they can support skin conditioning and hydration when used in appropriate formulations, though the evidence for dramatic anti-ageing effects remains mixed.

The ingredient appears in cosmetic formulations primarily for its conditioning properties rather than for evidence of strong biological activity. If you are interested in its use for a particular skin concern, it would be worth looking at the complete formulation and other active ingredients present, as individual components often work synergistically.

How to Use

This ingredient is typically found in leave-on products such as serums, moisturisers and treated products where it remains on the skin. Use as directed by the product instructions. Since it is a conditioning agent rather than an active treatment ingredient, it works best as part of a comprehensive skincare routine alongside other targeted ingredients suited to your skin concerns.

Safety & Precautions

Myristoyl Tetrapeptide-13 is generally well-tolerated in skincare formulations. Some users note that peptide-rich products may occasionally trigger fungal acne in acne-prone individuals, though this appears to be formulation-dependent rather than specific to this ingredient alone.

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