Preservative

O-Cymen-5-Ol

INCI: O-CYMEN-5-OL

Reviewed by Daisy · Last updated 14 Aug 2026

A phenolic preservative that protects skincare formulations from microbial contamination

Best For Skin Types

All

Effective Concentrations

Up to 0.5%

Usage Frequency

Daily

What Is O-Cymen-5-Ol?

O-Cymen-5-ol is a synthetic phenolic compound used primarily as a preservative and antimicrobial agent in skincare and cosmetic formulations. It belongs to a group of substituted phenols that help prevent the growth of bacteria, fungi, and other microorganisms that can compromise product stability and safety.

In skincare products, its role is largely invisible to the user—it works behind the scenes to maintain product integrity throughout its shelf life, rather than delivering direct benefits to the skin itself.

How It Works

O-Cymen-5-ol functions as a biocide by disrupting the cell membranes of bacteria and fungi, preventing their growth and reproduction. This antimicrobial activity allows it to serve as a preservative system component in cosmetic formulations.

As a preservative, it works to keep products free from microbial contamination over time, which is essential for maintaining the efficacy and safety of skincare formulations, particularly those with water content or other susceptible ingredients.

Clinical Evidence & References

O-Cymen-5-ol has undergone safety assessment by cosmetic regulatory bodies and is approved for use in cosmetics. The available evidence indicates it is generally well-tolerated when used at typical cosmetic concentrations, with a history of safe use in formulations.

Research on preservative compounds in this class suggests effective antimicrobial activity at low concentrations (typically around 0.5% or lower). However, specific clinical studies examining direct skin benefits are limited, as its primary function is preservation rather than active skincare efficacy.

How to Use

O-Cymen-5-ol is a preservative system ingredient, so you don't need to do anything differently when using a product containing it. Simply use the product as directed. Its presence in the ingredient list indicates the formulation has been designed to remain stable and safe throughout its use period.

Safety & Precautions

O-Cymen-5-ol is generally well-tolerated at cosmetic use levels. As with any ingredient, allergic contact sensitisation is possible in susceptible individuals, though this is rare.

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