Ovalicin

Ovalicin is a secondary metabolite produced by the fungus Metarhizium anisopliae. Originally identified for its use as a biological pest control agent in agriculture, it has recently become a subject of skincare research due to its immunomodulatory properties.In skincare formulations, ovalicin is being studied for its potential to address inflammatory skin conditions, particularly those involving itching and allergic responses. Its mechanism centres on dampening certain inflammatory signalling pathways in the skin.

Ovalicin appears to work by interrupting signalling pathways that trigger itching and inflammation. Specifically, it inhibits interleukin-31 (IL-31) signalling and reduces intracellular calcium influx—both processes known to amplify itching sensations and mast cell activation in inflammatory skin conditions.By suppressing these pathways, ovalicin may reduce the release of histamine and other inflammatory mediators, thereby reducing the urge to scratch and the underlying inflammatory cascade.

Ovalicin-containing products are not yet commonplace in skincare. If you are using a formulation that includes this ingredient, follow the manufacturer's instructions regarding application frequency and concentration. As research is ongoing, patch testing on a small area first is sensible, particularly if you have a history of skin sensitivity or allergic responses.

Ovalicin has shown immunosuppressive properties at high concentrations and may be more toxic when applied topically than when ingested systemically. Formulations for skincare use should be developed with careful concentration and safety protocols. Consult a dermatologist before use if you are pregnant, nursing, or taking immunosuppressive medications.