Orthosiphon Stamineus Leaf Extract
INCI: ORTHOSIPHON STAMINEUS LEAF EXTRACT
Reviewed by Daisy · Last updated 14 Aug 2026
A plant extract that may help regulate sebum production for a more balanced complexion
Best For Skin Types
Oily, Combination
Addresses
Usage Frequency
Daily
What Is Orthosiphon Stamineus Leaf Extract?
Orthosiphon stamineus leaf extract comes from a plant native to Southeast Asia, traditionally used in herbal medicine. In skincare formulations, it functions as a skin conditioning agent.
The extract appears to work by influencing the enzymes responsible for sebum production in the skin. This mechanism suggests potential use in formulations targeting oily or sebum-prone skin.
How It Works
Sebum production is regulated by enzymes called 5-α reductases. Research suggests Orthosiphon stamineus leaf extract may reduce the activity of one particular type of this enzyme (type 1 isozyme) in skin cells. By modulating this enzyme's expression, the extract could help regulate the amount of sebum the skin produces.
Since sebum production is also influenced by environmental factors like temperature and humidity, the ingredient may be most effective when combined with other oil-control strategies.
Clinical Evidence & References
In vitro studies have shown that Orthosiphon stamineus leaf extract can reduce 5-α reductase type 1 expression in human skin cells. Initial ex vivo testing (using tissue samples) has also suggested the extract may reduce enzyme activity and sebum production.
However, the evidence base remains limited, and clinical studies on human subjects are needed to confirm whether these laboratory findings translate to meaningful improvements in real-world use. Most current evidence comes from preliminary research rather than large-scale human trials.
How to Use
When incorporating products containing this ingredient, apply as directed in your skincare routine. It is typically found in serums, moisturisers and specialist oil-control products. Results may take several weeks to become apparent, so consistent use is worth maintaining before assessing efficacy.
Safety & Precautions
Frequently Asked Questions
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Orthosiphon Stamineus Leaf Extract is a variant of Orthosiphon Stamineus Extract, the form you will most often see on an ingredients list.
A plant extract studied for its potential to help regulate sebum production and reduce oily skin appearance
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