Skin Conditioning

Oxido Reductases

INCI: OXIDO REDUCTASES

Reviewed by Emma · Last updated 14 Aug 2026

Enzymes that support skin's natural antioxidant defences and cellular function

Best For Skin Types

All

Addresses

Oxidative stress, Skin conditioning, Cellular function

Usage Frequency

Daily

What Is Oxido Reductases?

Oxido reductases are a class of enzymes that catalyse oxidation-reduction (redox) reactions in biological systems. These proteins are found naturally in the body, where they play essential roles in cellular energy production, antioxidant defence, and metabolic processes. In skincare formulations, oxido reductases are included to support the skin's inherent enzymatic activity and help maintain cellular balance.

The skin relies on its own enzymatic systems to manage oxidative stress and maintain healthy cell function. By supplying exogenous oxido reductases, formulators aim to supplement these natural processes and promote skin conditioning at a cellular level.

How It Works

Oxido reductases function by facilitating electron transfer reactions that neutralise free radicals and support the body's natural antioxidant enzyme systems. The skin produces its own antioxidant enzymes (including superoxide dismutase and catalase) to protect against oxidative damage; oxido reductases work in conjunction with these systems.

At the cellular level, these enzymes help regulate redox balance, which influences cell signalling, energy production, and the expression of genes involved in skin health. This supports the skin's capacity to repair itself and maintain optimal function.

Clinical Evidence & References

Research indicates that selenoproteins (which function as oxido reductases) are integral to the skin's antioxidant defence system and are involved in thyroid hormone regulation and immune function. Trace elements like selenium and zinc are essential cofactors for oxido reductase enzymes; deficiency in these nutrients impairs the skin's ability to manage oxidative stress.

However, direct clinical evidence on topically applied oxido reductases in skincare formulations remains limited. Most research explores these enzymes in systemic biology rather than topical delivery. Further study is needed to establish optimal concentrations, bioavailability, and measurable benefits when applied to skin.

How to Use

Oxido reductases are typically incorporated into serums, moisturisers, and treatment products. These ingredients work best as part of a comprehensive skincare routine that includes sun protection and other antioxidants. They are generally suitable for daily use, though always follow product instructions. If you are using multiple active ingredients, introduce them gradually to monitor skin response.

Safety & Precautions

Oxido reductases derived from natural sources are generally well-tolerated by most skin types. However, individual sensitivity is possible; discontinue use if irritation develops and consult a dermatologist if concerns persist.

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