Peptides

Palmitoyl Dipeptide-7 Maltoside Tripeptide-69

INCI: PALMITOYL DIPEPTIDE-7 MALTOSIDE TRIPEPTIDE-69

Reviewed by Rosie · Last updated 14 Aug 2026

Also known as: Palmitoyl Dipeptide-7 Maltoside Tripeptide-69

A peptide-derived humectant that helps skin retain moisture and maintain hydration

Best For Skin Types

All, Dry, Combination, Mature

Addresses

Dryness, Hydration, Barrier repair

Usage Frequency

Daily

What Is Palmitoyl Dipeptide-7 Maltoside Tripeptide-69?

Palmitoyl Dipeptide-7 Maltoside Tripeptide-69 is a synthetic peptide-based ingredient created by combining amino acid sequences with a fatty acid (palmitic acid) and a sugar derivative (maltoside). This combination allows the ingredient to function as both a humectant and skin conditioning agent.

As a humectant, it works to draw moisture into the skin's outer layers. The peptide structure gives it additional skin-conditioning properties, meaning it can help maintain skin's hydration levels and support overall skin health when used in formulations.

How It Works

The ingredient functions on two levels. As a humectant, the sugar and peptide components are hygroscopic—meaning they naturally draw moisture from the environment and the deeper layers of skin into the stratum corneum (the skin's outermost layer). The fatty acid attachment (palmitoyl group) anchors the molecule to the skin surface, helping to maintain this hydrating effect.

The peptide portion also interacts with the skin's natural moisture-retention systems, potentially signalling skin cells to maintain optimal hydration and barrier function without disrupting normal skin physiology.

Clinical Evidence & References

Published clinical data on this specific ingredient combination is limited. However, peptide-based humectants and the individual components (dipeptides, tripeptides, and maltoside sugars) have been studied in skincare formulations and show promise in supporting skin hydration and conditioning when used appropriately.

Most evidence for this ingredient comes from formulation studies and cosmetic efficacy testing rather than independent peer-reviewed research. Its inclusion in skincare products suggests manufacturers have found it effective for hydration purposes, though individual results may vary depending on formulation and skin condition.

How to Use

This ingredient is typically used in moisturisers, serums, and hydrating products. It works well alongside other humectants like glycerin or hyaluronic acid, and can be used daily as part of a regular skincare routine. If introducing it for the first time, use it consistently for at least 2–4 weeks to assess any changes in skin hydration.

Safety & Precautions

This ingredient is generally well-tolerated and considered safe for topical skincare use. It has low risk of irritation, though as with any new product, patch testing is sensible if you have very reactive or sensitive skin.

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