Palmitoyl Tetrapeptide-20

Palmitoyl tetrapeptide-20 is a synthetic peptide—a short chain of amino acids—designed to mimic alpha-melanocyte-stimulating hormone (α-MSH), a naturally occurring signalling molecule in the body. The ingredient is created by attaching a fatty acid (palmitic acid) to a four-amino-acid peptide sequence, which helps it penetrate and remain stable in skincare formulations.In cosmetic products, palmitoyl tetrapeptide-20 functions primarily as an antioxidant. It is formulated to support the skin's natural defences against oxidative stress, which accumulates from environmental exposure and ageing…

Palmitoyl tetrapeptide-20 works by mimicking α-MSH, a signalling molecule that influences melanin production and antioxidant enzyme activity in skin cells. When applied topically, it is thought to interact with melanocortin receptors on skin cells, triggering pathways that enhance the activity of protective enzymes such as catalase, which neutralises hydrogen peroxide and other harmful reactive oxygen species.By supporting these natural antioxidant mechanisms, the ingredient may help protect skin from cumulative oxidative damage that contributes to premature ageing and pigmentation irregula…

Palmitoyl tetrapeptide-20 is typically found in serums, moisturisers, and targeted treatments. For best results, apply to clean skin as part of your daily routine. As with other peptides, consistency matters—allow 4 to 8 weeks of regular use to assess any visible changes. It works well alongside other antioxidants such as vitamin C or niacinamide, though layering should be guided by your skin's tolerance.

Palmitoyl tetrapeptide-20 is generally considered well-tolerated and suitable for most skin types. No significant adverse effects have been reported in cosmetic use, though those with very sensitive skin should perform a patch test before full application.