Peptides

Palmitoyl Tetrapeptide-10

Reviewed by Emma · Last updated 18 Aug 2026

Also known as: Crystalide, SpecPed® P4T10P

Synthetic peptide | Not widely used in cosmetics

Addresses

Ageing

What Is Palmitoyl Tetrapeptide-10?

Palmitoyl tetrapeptide-10 is a cosmetic ingredient – a synthetic peptide – obtained through the reaction of palmitic acid and tetrapeptide-10. Lysine, threonine and phenylalanine are the amino acids whose sequence comprises this peptide. It is marketed under the trade names Crystalide™, which is a blend of the protein with carrier compounds, and SpecPed® P4T10P.

At the time of this writing, this peptide isn’t in wide use in cosmetics and there isn’t a breadth of independent research regarding its efficacy in skin care products. Its manufacturer claims palmitoyl tetrapeptide-10 promotes skin brightness and smoothness by speeding up skin’s shedding process.

The independent Cosmetic Ingredient Review considers palmitoyl tripeptide-10 a skin conditioning ingredient. Used on its own, the recommended concentration is 0.0006%.

Clinical Evidence & References

Published Research

  • UL Prospector, Website, Accessed February 2025 [https://www.ulprospector.com/]
  • Journal of Cosmetic Dermatology, December 2024, pages 4,325-4,333 [https://onlinelibrary.wiley.com/doi/10.1111/jocd.16529]

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