Palmitoyl Sh-Tripeptide-3 Amide

Palmitoyl Sh-Tripeptide-3 Amide is a synthetic peptide—a short chain of amino acids—combined with a fatty acid (palmitic acid). Peptides are fragments of proteins, and this particular combination is designed to mimic and support natural skin structures involved in hydration and protection.In skincare formulations, it functions as a humectant (drawing moisture into the skin), a skin conditioner (softening and smoothing the skin surface), and a protective agent that helps maintain skin integrity.

The peptide component signals to skin cells, whilst the fatty acid (palmitoyl) portion allows the ingredient to integrate into the skin's lipid layer—the oily matrix that holds cells together and retains moisture. This dual action means it can work both at the cellular communication level and within the skin's structural barrier.As a humectant, it draws water molecules into the outer layers of the skin. By mimicking the structure of skin's natural lipids, it may also help reinforce the barrier's ability to lock this moisture in and prevent dehydration.

Palmitoyl Sh-Tripeptide-3 Amide is typically found in serums, moisturisers, and barrier-repair products. It works well layered with other hydrating or barrier-supporting ingredients such as ceramides, hyaluronic acid, or niacinamide. Apply to clean, damp skin for optimal hydration benefit, or use as directed by the product formulation.

Generally well-tolerated in skincare products. As a peptide-derived ingredient, it is unlikely to cause irritation in most users, though those with extreme sensitivity to peptides (rare) should patch test first.