Palmitoyl Sh-Tripeptide-1 Amide

Palmitoyl Sh-Tripeptide-1 Amide is a synthetic peptide derived from amino acids, modified with a palmitoyl (fatty acid) chain attached to its structure. This modification allows it to interact with the skin's outer layers more effectively than unmodified peptides.In skincare formulations, it functions primarily as a humectant—drawing moisture into the skin—and as a skin conditioning agent. The fatty acid component may also help support the skin's lipid barrier, which is essential for maintaining hydration and protecting against irritants.

As a humectant, Palmitoyl Sh-Tripeptide-1 Amide attracts water molecules from deeper skin layers and the environment, drawing them into the outer epidermis. This increases hydration levels within the stratum corneum, the skin's outermost protective layer.The palmitoyl (fatty acid) chain attached to the peptide allows the ingredient to interact with the skin's lipid barrier—the naturally occurring fats that cement skin cells together. By supporting lipid content and organisation, it may help reduce moisture loss and strengthen the skin's defence against environmental stressors.

This ingredient is typically used in serums, moisturisers, and hydrating essences. Apply to clean, slightly damp skin for optimal hydration. It works well in layered routines—use it before occlusive moisturisers to seal in hydration. There is no upper limit on daily use; most formulations containing this ingredient are designed for twice-daily application as part of a standard skincare regimen.

Palmitoyl Sh-Tripeptide-1 Amide is generally well-tolerated across all skin types, including sensitive and reactive skin. No significant contraindications or safety concerns are documented.