Palmitoyl Tripeptide-5 Amidopropyl Ascorbyl Phosphate Hcl
INCI: PALMITOYL TRIPEPTIDE-5 AMIDOPROPYL ASCORBYL PHOSPHATE HCL
Reviewed by Rosie · Last updated 2 Jun 2026
Also known as: Palmitoyl Tripeptide-5 Amidopropyl Ascorbyl Phosphate Hcl
A stabilised vitamin C peptide blend designed to condition and support skin resilience
Best For Skin Types
All, Dry, Sensitive, Mature
Addresses
Usage Frequency
Daily
What Is Palmitoyl Tripeptide-5 Amidopropyl Ascorbyl Phosphate Hcl?
Palmitoyl Tripeptide-5 Amidopropyl Ascorbyl Phosphate HCl is a hybrid ingredient that combines a stabilised form of vitamin C with a short peptide chain. Vitamin C (in this esterified form) is a well-established antioxidant, whilst the tripeptide component is a small protein fragment designed to support skin conditioning. This combination is formulated to enhance skin texture and resilience.
The ingredient functions primarily as a skin conditioner, helping to maintain the skin's barrier function and overall appearance. It is typically used in serums and treatment products at modest concentrations.
How It Works
The vitamin C portion works as an antioxidant, neutralising free radicals that can damage skin cells and contribute to visible ageing. The esterified (stabilised) form makes it more shelf-stable and less irritating than raw ascorbic acid, whilst still offering antioxidant benefits.
The tripeptide acts as a signalling molecule, potentially supporting the skin's natural conditioning processes and barrier maintenance. Together, these components work to protect and condition the skin rather than driving dramatic structural changes.
Clinical Evidence & References
Evidence specific to this combined ingredient is limited in peer-reviewed literature. However, both stabilised vitamin C and peptides have established track records in skincare. Vitamin C is well-documented for its antioxidant and collagen-supporting properties, whilst peptides are recognised for their role in skin conditioning and barrier support.
This particular formulation appears designed to offer a gentler alternative to pure ascorbic acid whilst maintaining some of vitamin C's benefits. Real-world efficacy will depend on formulation, pH, and concentration, so individual results may vary.
How to Use
Use as directed by the product instructions, typically once or twice daily in a serum or treatment. Apply to clean skin before moisturiser. This ingredient works well in layered routines and does not typically require special pairing restrictions, though it may be combined with other antioxidants for enhanced protection. Allow the product to absorb fully before applying subsequent layers.
Safety & Precautions
Frequently Asked Questions
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