Peptides

Palmitoyl Tripeptide-5 Amidopropyl Ascorbyl Phosphate Hcl

INCI: PALMITOYL TRIPEPTIDE-5 AMIDOPROPYL ASCORBYL PHOSPHATE HCL

Reviewed by Rosie · Last updated 2 Jun 2026

Also known as: Palmitoyl Tripeptide-5 Amidopropyl Ascorbyl Phosphate Hcl

A stabilised vitamin C peptide blend designed to condition and support skin resilience

Best For Skin Types

All, Dry, Sensitive, Mature

Addresses

Fine lines, Dryness, Barrier repair

Usage Frequency

Daily

What Is Palmitoyl Tripeptide-5 Amidopropyl Ascorbyl Phosphate Hcl?

Palmitoyl Tripeptide-5 Amidopropyl Ascorbyl Phosphate HCl is a hybrid ingredient that combines a stabilised form of vitamin C with a short peptide chain. Vitamin C (in this esterified form) is a well-established antioxidant, whilst the tripeptide component is a small protein fragment designed to support skin conditioning. This combination is formulated to enhance skin texture and resilience.

The ingredient functions primarily as a skin conditioner, helping to maintain the skin's barrier function and overall appearance. It is typically used in serums and treatment products at modest concentrations.

How It Works

The vitamin C portion works as an antioxidant, neutralising free radicals that can damage skin cells and contribute to visible ageing. The esterified (stabilised) form makes it more shelf-stable and less irritating than raw ascorbic acid, whilst still offering antioxidant benefits.

The tripeptide acts as a signalling molecule, potentially supporting the skin's natural conditioning processes and barrier maintenance. Together, these components work to protect and condition the skin rather than driving dramatic structural changes.

Clinical Evidence & References

Evidence specific to this combined ingredient is limited in peer-reviewed literature. However, both stabilised vitamin C and peptides have established track records in skincare. Vitamin C is well-documented for its antioxidant and collagen-supporting properties, whilst peptides are recognised for their role in skin conditioning and barrier support.

This particular formulation appears designed to offer a gentler alternative to pure ascorbic acid whilst maintaining some of vitamin C's benefits. Real-world efficacy will depend on formulation, pH, and concentration, so individual results may vary.

How to Use

Use as directed by the product instructions, typically once or twice daily in a serum or treatment. Apply to clean skin before moisturiser. This ingredient works well in layered routines and does not typically require special pairing restrictions, though it may be combined with other antioxidants for enhanced protection. Allow the product to absorb fully before applying subsequent layers.

Safety & Precautions

Generally well-tolerated by most skin types. The stabilised vitamin C form is typically gentler than pure ascorbic acid. Those with very sensitive skin or known sensitivities to peptides should patch-test first.

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