Perilla Frutescens Extract
INCI: PERILLA FRUTESCENS EXTRACT
Reviewed by Daisy · Last updated 14 Aug 2026
A traditional herb extract with emerging evidence for skin barrier support and antioxidant protection
Best For Skin Types
All, Sensitive, Dry, Combination
Addresses
Usage Frequency
Daily
What Is Perilla Frutescens Extract?
Perilla frutescens extract is derived from the leaves of the perilla plant, a herb traditionally used in East Asian medicine for centuries. The extract contains flavonoids, essential oils, and fatty acids—compounds recognised for their antioxidant and anti-inflammatory properties.
In skincare formulations, perilla frutescens extract functions as a skin conditioning agent, helping to support the skin's natural protective mechanisms and overall appearance.
How It Works
Perilla frutescens extract appears to work through multiple pathways. Its antioxidant compounds may help reduce inflammation and protect skin cells from oxidative damage caused by UV exposure and environmental stressors. The extract also shows potential to support the skin's natural barrier by promoting filaggrin expression—a key protein involved in moisture retention and barrier integrity.
Research suggests it may activate signalling pathways (such as AhR signalling) that regulate skin barrier function and help maintain the skin's protective properties. However, most evidence to date comes from laboratory and animal studies; human clinical data remains limited.
Clinical Evidence & References
Research into perilla frutescens extract is still developing. Laboratory studies on human skin cells and animal models show promising results: the extract demonstrated ability to reduce UV-induced damage to skin structure, support barrier function markers, and reduce signs of inflammation in psoriasis-like lesions. A study using a mixed botanical extract containing perilla also found oral administration improved dry skin and itch symptoms in mice and promoted filaggrin expression in skin cells.
However, human clinical trials are limited. The evidence base is strongest for antioxidant and anti-inflammatory activity. More research in human subjects would help establish efficacy and optimal use in skincare formulations.
Published Research
How to Use
Perilla frutescens extract is typically used as part of a formulated product rather than in isolation. It works well alongside other barrier-supporting and antioxidant ingredients. Use as directed on your chosen product—whether that's a serum, moisturiser, or treatment—and allow time to observe any benefit, as barrier and antioxidant effects often take consistent use over weeks to become apparent.
Safety & Precautions
Frequently Asked Questions
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Perilla Frutescens Extract is a variant of Perilla Ocymoides Seed Extract, the form you will most often see on an ingredients list.
A plant-derived antioxidant from perilla seed that helps protect skin from environmental stress
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