Polygonum Multiflorum Root Extract
INCI: POLYGONUM MULTIFLORUM ROOT EXTRACT
Reviewed by Rosie · Last updated 14 Aug 2026
A traditional plant extract with emerging evidence for skin conditioning and pigmentation support
Best For Skin Types
All
Addresses
Usage Frequency
Daily
What Is Polygonum Multiflorum Root Extract?
Polygonum multiflorum root extract is derived from the roots of Polygonum multiflorum (also known as Fo-Ti), a plant used historically in traditional Asian medicine. The extract contains several bioactive compounds, including phenolic constituents and stilbenes, which are isolated through solvent extraction methods.
In skincare formulations, this ingredient functions primarily as a skin conditioner. It has been incorporated into traditional formulas used to address inflammatory skin conditions and support overall skin health, though its use in modern cosmetics remains relatively uncommon.
How It Works
The extract's key active components, particularly a compound called THSG (tetrahydroxystilbene glucoside), appear to work through multiple pathways. Research suggests THSG may activate cellular signalling cascades involved in melanin production, specifically by upregulating tyrosinase activity and influencing the MAP kinase pathway.
The phenolic constituents in the extract also possess antioxidant properties, which may help neutralise free radicals and support the skin's natural defence mechanisms. Additionally, traditional use suggests the extract may promote circulation in the skin, though this mechanism requires further investigation in a skincare context.
Clinical Evidence & References
Research into polygonum multiflorum root extract remains limited, with most studies conducted in cell cultures or animal models rather than human skin. Laboratory studies have demonstrated that isolated compounds from the plant can promote cell proliferation in dermal papilla cells and increase melanin production in melanoma cell lines, but translating these findings to practical skincare benefits requires caution.
The extract's historical use in traditional medicine for inflammatory skin conditions suggests potential anti-inflammatory activity, and it has been included in traditional formulas for eczema and dermatitis. However, human clinical trials specifically examining this ingredient's efficacy in skincare products are sparse, so claims should be considered preliminary rather than established.
Published Research
How to Use
As polygonum multiflorum root extract is typically used in small concentrations within formulations, there are no specific usage guidelines beyond following the product instructions. It is generally incorporated into serums, toners, or treatment products as part of a broader formulation, rather than used as a standalone ingredient.
Safety & Precautions
Frequently Asked Questions
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