Polyoxymethylene Glycol Urea
INCI: POLYOXYMETHYLENE GLYCOL UREA
Reviewed by Emma · Last updated 14 Aug 2026
Also known as: Polyoxymethylene Glycol Urea
A synthetic preservative that helps protect skincare formulations from microbial growth
Best For Skin Types
All
Usage Frequency
As part of finished formulations
What Is Polyoxymethylene Glycol Urea?
Polyoxymethylene glycol urea is a synthetic preservative commonly used in cosmetic and skincare formulations. It works by releasing formaldehyde in a controlled manner, which provides antimicrobial protection without requiring high concentrations of formaldehyde itself. This mechanism allows formulators to preserve products effectively whilst minimising exposure to free formaldehyde.
As a preservative system, its primary role is to prevent the growth of bacteria, fungi and other microorganisms that could otherwise compromise product safety and stability over time. It is typically used in leave-on and rinse-off products across various skincare categories.
How It Works
Polyoxymethylene glycol urea is a condensation product that releases formaldehyde gradually within a skincare formulation. This controlled release mechanism provides antimicrobial activity at relatively low concentrations, preventing the proliferation of bacteria and fungi that could otherwise cause product spoilage or pose hygiene risks.
Because the formaldehyde release is regulated by the formulation's pH and water content, the ingredient functions as a gentle preservative system rather than introducing high levels of free formaldehyde directly into the product.
Clinical Evidence & References
Polyoxymethylene glycol urea has a long history of use in cosmetic preservation and is recognised as effective against a broad spectrum of microorganisms. Its antimicrobial properties have been well-documented in preservation efficacy studies within the cosmetic industry.
However, specific dermatological studies examining its direct effects on skin are limited. Its primary benefit lies in product preservation rather than active skincare benefits. As with any preservative system, individual tolerance may vary, and sensitivities are typically mild.
How to Use
Polyoxymethylene glycol urea is a preservative system present in finished products; it is not an ingredient you would apply separately or adjust the frequency of. Simply use the product as directed by the manufacturer. If you notice any signs of product degradation such as separation, discolouration or unusual odour, discontinue use and obtain a fresh product.
Safety & Precautions
Frequently Asked Questions
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