Polypeptide-1

Polypeptide-1 is a short-chain peptide—a fragment of amino acids—used in skincare formulations primarily for its skin-conditioning properties. Peptides are naturally occurring compounds that can be derived from various sources and are commonly used in cosmetics to support the skin's structural integrity and moisture retention.In topical skincare, Polypeptide-1 functions as a humectant and conditioning agent, helping to maintain skin hydration and support a smoother skin texture. It works at the surface level to improve how skin feels and appears.

Polypeptide-1 functions as a skin conditioner by binding water to the outer layers of the skin and forming a protective film. This helps prevent transepidermal water loss (TEWL)—the process by which moisture evaporates from the skin.The peptide also supports the skin's natural moisture-binding capacity, which can be particularly beneficial in drier conditions or for products formulated to improve overall skin comfort and appearance.

Polypeptide-1 is typically used as part of a formulated product rather than as a standalone ingredient. It works well in serums, moisturisers, and hydrating treatments. For best results, apply to clean skin and layer with other compatible products. There is no known upper concentration limit for use, though formulation concentrations vary by product.

Polypeptide-1 is generally well-tolerated and considered safe for topical use. It is unlikely to cause irritation for most skin types, though those with extremely sensitive skin should patch-test new products containing peptides.