Propylene Glycol Laurate
INCI: PROPYLENE GLYCOL LAURATE
Reviewed by Daisy · Last updated 14 Aug 2026
A penetration enhancer that helps active ingredients reach deeper skin layers
Best For Skin Types
All
Addresses
Usage Frequency
Daily
What Is Propylene Glycol Laurate?
Propylene glycol laurate is a synthetic compound derived from propylene glycol (a common humectant) and lauric acid (a fatty acid). It functions as both a skin conditioning agent and a surfactant—meaning it can help reduce the surface tension between ingredients, improving how they spread and absorb into the skin.
In formulations, it serves primarily as a penetration enhancer, assisting other active ingredients in crossing the skin barrier more effectively. This makes it particularly useful in products designed to deliver actives like niacinamide or other water-soluble compounds deeper into the epidermis.
How It Works
Propylene glycol laurate works by temporarily altering the skin barrier's lipid composition, making it more permeable to other ingredients. When applied topically, it penetrates the outer layers of skin and creates pathways that allow larger or more challenging molecules to pass through more readily.
This mechanism is particularly useful when formulating products with actives that would otherwise struggle to reach therapeutic concentrations in the deeper epidermis. However, this enhanced permeability is temporary and reversible, with the barrier returning to normal once the ingredient is removed or metabolised.
Clinical Evidence & References
Research indicates that propylene glycol laurate is an effective skin penetration enhancer, improving the delivery of various actives including niacinamide. Studies comparing it alongside other enhancers (such as propylene glycol and N-methyl 2-pyrrolidone) suggest it performs favourably in controlled settings.
However, the evidence base remains relatively limited to in vitro and short-term in vivo studies. While it appears well-tolerated in research contexts, long-term safety data on frequent use in leave-on products is sparse. More research would help clarify optimal concentration ranges and potential effects on skin barrier health with extended use.
How to Use
Propylene glycol laurate is typically found in serums, targeted treatments, and delivery-focused formulations rather than everyday moisturisers. For best results, apply it to clean, slightly damp skin to maximise penetration of accompanying actives. If using multiple penetration enhancers in your routine, apply them separately rather than layering to avoid over-disrupting the skin barrier.
Safety & Precautions
Frequently Asked Questions
From the Clinic
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PPG-1 Trideceth-6
A lightweight humectant and surfactant that conditions skin and aids formula stability
Prebiotic Complex
Feeds beneficial bacteria for microbiome health
Propylene Glycol Isostearate
Mixture of propylene glycol and isostearic acid used as an emollient and emulsifier.
Propylene Glycol Oleate
A multi-functional ester that conditions skin and helps formulations blend
Quaternium-87
A synthetic conditioning agent primarily used in hair and cleansing products
Rice Bran Acid
A mild cleansing ingredient derived from rice processing by-products
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