Antioxidant

Pyridoxine Hydroxybenzoate

INCI: PYRIDOXINE HYDROXYBENZOATE

Reviewed by Daisy · Last updated 2 Jun 2026

Also known as: Pyridoxine Hydroxybenzoate

A vitamin B6 derivative that works as an antioxidant and skin conditioning agent

Best For Skin Types

All

Addresses

Oxidative stress, Environmental damage

Usage Frequency

Daily

What Is Pyridoxine Hydroxybenzoate?

Pyridoxine hydroxybenzoate is a stabilised form of vitamin B6 (pyridoxine), combined with hydroxybenzoic acid. This derivative is used in skincare formulations primarily for its antioxidant and skin conditioning properties. As a water-soluble ingredient, it can penetrate the outer layers of the skin to deliver its benefits.

The ingredient functions as a free radical neutraliser, helping to protect skin from oxidative stress caused by environmental factors such as pollution and UV exposure. Beyond antioxidant activity, it also conditions the skin, supporting overall skin health and appearance.

Benefits for Your Skin

How It Works

Pyridoxine hydroxybenzoate works by donating electrons to free radicals, effectively neutralising them before they can cause cellular damage. This antioxidant mechanism is particularly relevant in the context of environmental stressors like pollution and photoaging.

As a skin conditioner, the ingredient helps maintain skin hydration and supports the skin's barrier function, contributing to improved texture and a more resilient complexion.

Clinical Evidence & References

Research specifically examining pyridoxine hydroxybenzoate in skincare formulations is limited. The ingredient is primarily referenced in cosmetic chemistry literature for its dual function as an antioxidant and conditioning agent, though comprehensive clinical data on its efficacy in consumer skincare products is sparse.

Vitamin B6 more broadly has been studied for various dermatological applications, but evidence specific to this stabilised derivative and its performance in topical skincare remains unclear. Further clinical study would help clarify its contribution to skin health outcomes.

How to Use

Pyridoxine hydroxybenzoate is typically found in finished skincare products rather than used as a standalone treatment. It works well in antioxidant serums and moisturisers designed for daily protection. For best results, use consistently as part of your regular skincare routine, ideally morning and evening, and combine with other sun protection measures during the day.

Safety & Precautions

Pyridoxine hydroxybenzoate is generally well-tolerated in skincare formulations. Those with known sensitivity to B vitamins or hydroxybenzoic acid derivatives should patch test first.

Frequently Asked Questions

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