Retinol/Saccharomyces Polypeptide

This ingredient pairs retinol, a vitamin A derivative, with saccharomyces polypeptide — a peptide complex derived from yeast fermentation. Retinol is a well-established compound in skincare, whilst the polypeptide component adds amino acid-based conditioning properties to the formulation.Together, they function primarily as a skin-conditioning agent, working to support the skin's texture and appearance. The combination format allows formulators to deliver retinoid activity alongside additional hydrating and nourishing peptides in a single ingredient.

Retinol is converted in the skin to retinoic acid, which binds to retinoid receptors in cells and influences gene expression related to cell turnover and collagen production. This encourages the shedding of older surface cells and supports renewal from beneath.The saccharomyces polypeptide component complements this by delivering amino acids and small proteins that hydrate and condition the skin barrier, potentially offsetting any dryness that can occur with retinoid use alone.

Start with 2-3 times per week if you are new to retinoids, gradually increasing frequency as your skin adapts. This ingredient is best applied to clean, dry skin in the evening, followed by a moisturiser to support barrier health. Avoid combining with other active ingredients (such as vitamin C or acids) until you are confident in your skin's tolerance. Always use sunscreen during the day, as retinol can increase sun sensitivity.

Retinol can cause temporary redness, dryness, or sensitivity, particularly when first introduced. Those with very sensitive skin should patch-test first and introduce gradually. Avoid during pregnancy, and do not use if you are taking oral retinoid medications without consulting a healthcare provider. If you're pregnant or breastfeeding, please check with us first — hello@skintique.co.uk.