S-Arachidonoyl …
INCI: S-ARACHIDONOYL/LINOLENOYL/LINOLEOYL GLUTATHIONE
Reviewed by Daisy · Last updated 2 Jun 2026
Also known as: S-arachidonoyl/linolenoyl/linoleoyl Glutathione
A glutathione conjugate designed to neutralise free radicals and support skin antioxidant defences
Best For Skin Types
All, Sensitive, Mature
Addresses
Usage Frequency
Daily
What Is S-Arachidonoyl …?
S-Arachidonoyl/Linolenoyl/Linoleoyl Glutathione is a modified form of glutathione, a naturally occurring tripeptide (three amino acids bound together) with established antioxidant properties. This particular variant has been chemically conjugated with long-chain fatty acids—arachidonic acid, linolenic acid, and linoleic acid—to enhance its stability and skin penetration in cosmetic formulations.
Glutathione itself is one of the body's primary endogenous antioxidants, involved in neutralising reactive oxygen species (ROS) and supporting cellular defence mechanisms. The fatty acid modifications allow this ingredient to remain effective in topical products where unmodified glutathione would degrade rapidly.
Benefits for Your Skin
How It Works
Free radicals are unstable molecules generated by UV exposure, pollution, and normal cellular metabolism. These unstable molecules can damage cellular structures including lipids, proteins, and DNA, contributing to premature ageing and inflammation. Antioxidants like glutathione work by donating electrons to neutralise free radicals, converting them into harmless compounds.
The fatty acid conjugation in this ingredient allows it to integrate into the skin's lipid matrix more effectively than standard glutathione, potentially improving both stability during storage and bioavailability once applied to skin.
Clinical Evidence & References
Research specifically on this conjugated form of glutathione in topical skincare is limited. Most evidence derives from studies on glutathione itself or similar glutathione derivatives, which demonstrate antioxidant capacity in laboratory and some in vivo settings.
While the principle of antioxidant protection is well-established in skin biology, the real-world efficacy of this particular ingredient at typical cosmetic concentrations remains unclear. More targeted human studies would help clarify its clinical benefit compared to other established antioxidants.
How to Use
This ingredient is typically found in serums, moisturisers, and treatment products. It works best as part of a broader skincare routine that includes sun protection, since antioxidants are most effective when combined with daily SPF to prevent ongoing free radical generation. Layer it under heavier creams if using in serum form, and allow adequate time for absorption before applying other products.
Safety & Precautions
Frequently Asked Questions
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