Saccharomyces Ferment Lysate Filtrate
INCI: SACCHAROMYCES FERMENT LYSATE FILTRATE
Reviewed by Daisy · Last updated 2 Jun 2026
A fermented ingredient studied for its role in supporting skin barrier recovery and antioxidant defence
Best For Skin Types
All, Sensitive, Dry
Addresses
Usage Frequency
Daily
What Is Saccharomyces Ferment Lysate Filtrate?
Saccharomyces ferment lysate filtrate is derived from fermented yeast (Saccharomyces cerevisiae), combined with pearl extract. The ingredient is created through a fermentation process that breaks down the yeast cells, resulting in a filtrate—a liquid containing the bioactive compounds released during fermentation. This combination harnesses both the fermentation byproducts and pearl's known antioxidant properties.
In skincare formulations, this ingredient functions primarily as a skin conditioner, working to support the skin's natural barrier and protective systems.
How It Works
The ingredient appears to work through multiple pathways. It activates cellular antioxidant defence systems—specifically triggering pathways like Nrf2/HO-1 that encourage the skin to produce its own protective proteins. This helps reduce the accumulation of reactive oxygen species (ROS), which damage skin cells and accelerate barrier breakdown.
Additionally, saccharomyces ferment lysate filtrate may help regulate inflammatory signalling pathways and support the expression of proteins essential for tight junctions and moisture-holding capacity in the epidermis. The combined effect is a strengthened barrier and reduced inflammatory response.
Clinical Evidence & References
Current research is limited but suggestive. One study demonstrated that saccharomyces/pearl ferment lysate filtrate reduced markers of UV-induced skin damage in cell cultures and animal models, including improvements in skin peeling, redness, and barrier thickness. The ingredient appeared to restore key barrier proteins and lower inflammatory markers.
However, human clinical studies are lacking, and the evidence base remains small. The ingredient is found in fewer than 1% of skincare products, suggesting limited commercial use or validation to date. Further human studies would help clarify its real-world efficacy and optimal usage patterns.
How to Use
This ingredient is typically used in serums, essences, and toners at low concentrations as part of a wider formulation. It can be layered with other actives, though there are no specific contraindications documented. If your skin is reactive or compromised, introduce it gradually and monitor for tolerance over 1–2 weeks before regular use.
Safety & Precautions
Frequently Asked Questions
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