Prebiotic/Probiotic/Postbiotic

Saccharomyces/Niacinamide Ferment Lysate Filtrate

INCI: SACCHAROMYCES/NIACINAMIDE FERMENT LYSATE FILTRATE

Reviewed by Daisy · Last updated 2 Jun 2026

Also known as: Saccharomyces/niacinamide Ferment Lysate Filtrate

A fermented niacinamide derivative that combines antioxidant and skin-protective properties

Best For Skin Types

All, Oily, Combination, Acne-prone

Addresses

Oil control, Antioxidant protection, Barrier repair, Redness

Usage Frequency

Daily

What Is Saccharomyces/Niacinamide Ferment Lysate Filtrate?

Saccharomyces/Niacinamide Ferment Lysate Filtrate is a fermented ingredient created by cultivating Saccharomyces yeast in the presence of niacinamide (vitamin B3), then filtering the resulting lysate. The fermentation process breaks down the yeast cells, releasing intracellular components and creating a concentrated filtrate rich in niacinamide and fermentation byproducts.

This ingredient functions primarily as an antioxidant and skin protectant. The niacinamide content contributes to the ingredient's activity, whilst the fermentation-derived components may offer additional benefits through their composition of amino acids, peptides, and other bioactive molecules.

Benefits for Your Skin

How It Works

Niacinamide works by supporting the synthesis of ceramides and other lipids essential to the skin barrier, and by enhancing the skin's natural moisturising factors. As an antioxidant, it scavenges reactive oxygen species that can damage skin cells and accelerate visible ageing.

The fermentation process generates additional bioactive compounds—including free amino acids and small peptides—that may enhance penetration or provide complementary skin-conditioning effects. However, the specific contribution of fermentation-derived components beyond the niacinamide content is not extensively documented in published research.

Clinical Evidence & References

Niacinamide itself has substantial clinical support for barrier function, sebum regulation, and antioxidant activity. Studies demonstrate its effectiveness at concentrations as low as 2-5% for visible improvements in skin hydration, pore appearance, and redness reduction.

Evidence specific to the fermented niacinamide lysate format is limited. Fermentation-based skincare ingredients show promise in preliminary studies, but more rigorous clinical data is needed to confirm whether the fermentation process meaningfully enhances niacinamide's efficacy or adds distinct benefits beyond the vitamin B3 component alone.

How to Use

This ingredient is typically found in serums, essences, and moisturisers. Apply to clean skin before heavier creams or oils. It pairs well with other antioxidants and barrier-supporting ingredients. If using in a routine with other active ingredients, introduce gradually to monitor tolerance. No specific restrictions on layering, though it works synergistically with other niacinamide-containing products—assess your full routine to avoid excessive niacinamide concentration if desired.

Safety & Precautions

Niacinamide and fermented yeast derivatives are generally well-tolerated by most skin types. Rarely, niacinamide can cause mild flushing or sensitivity in individuals with very reactive skin; those with yeast sensitivities should patch test first.

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